内膜厚度与人体右冠状动脉的壁面切应力模式无关。
Intimal thickness is not associated with wall shear stress patterns in the human right coronary artery.
作者信息
Joshi Anil K, Leask Richard L, Myers Jerry G, Ojha Matadial, Butany Jagdish, Ethier C Ross
机构信息
Department of Mechanical and Industrial Engineering, University of Toronto, Ontario, Canada.
出版信息
Arterioscler Thromb Vasc Biol. 2004 Dec;24(12):2408-13. doi: 10.1161/01.ATV.0000147118.97474.4b. Epub 2004 Oct 7.
OBJECTIVE
Low wall shear stress has been implicated in atherogenesis throughout the arterial tree, including the right coronary artery (RCA). The objective of this study was to determine the level of covariation of intimal thickness and wall shear stress in the human RCA.
METHODS AND RESULTS
Postmortem histological measurements of intimal thickness were compared with wall shear stresses calculated from computational flow modeling in 4 human right coronary arteries. A statistically significant correlation between intimal thickness and wall shear stress was found in only 1 of the 4 arteries studied.
CONCLUSIONS
Wall shear stress does not appear to be related to intimal thickness in the 4 RCAs studied.
目的
低壁面切应力与包括右冠状动脉（RCA）在内的整个动脉树的动脉粥样硬化形成有关。本研究的目的是确定人类右冠状动脉内膜厚度与壁面切应力的协变水平。
方法与结果
对4条人类右冠状动脉的内膜厚度进行尸检组织学测量，并与通过计算流体动力学模型计算出的壁面切应力进行比较。在研究的4条动脉中，仅在1条动脉中发现内膜厚度与壁面切应力之间存在统计学显著相关性。
结论
在所研究的4条右冠状动脉中，壁面切应力似乎与内膜厚度无关。
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