Pedersen E M, Oyre S, Agerbaek M, Kristensen I B, Ringgaard S, Boesiger P, Paaske W P
Institute of Experimental Clinical Research, Aarhus University Hospital, Skejby Sygehus, Denmark.
Eur J Vasc Endovasc Surg. 1999 Oct;18(4):328-33. doi: 10.1053/ejvs.1999.0913.
to study the relationship between wall shear stresses measured in vivo and early atherosclerotic lesions in the abdominal aorta.
eight young volunteers for in vivo wall shear-stress measurements. Abdominal aortas from 10 young adults without signs or history of atherosclerotic disease were obtained by autopsy for histomorphometric measurements.
wall shear stresses were measured in the abdominal aorta above and below the renal arteries using a magnetic resonance technique with high resolution for imaging and blood velocity mapping. At identical abdominal aortic locations, intimal thickness was measured blindly using histomorphometric techniques and correlated to wall shear-stress variables using linear-regression analysis.
intimal thickness showed a linear decrease with mean wall shear stress (r=-0.90, p<0.01) and with maximum wall shear stress (r=-0.86, p<0.01).
intimal thickness in the normal abdominal aorta is associated with mean, maximum and oscillating wall shear stresses. These in vivo data corroborate previous in vitro studies suggesting that low and oscillating wall shear stresses are localising factors for intimal thickening and hence the early development of atherosclerosis.
研究体内测量的壁面剪应力与腹主动脉早期动脉粥样硬化病变之间的关系。
八名年轻志愿者用于体内壁面剪应力测量。通过尸检获取了10名无动脉粥样硬化疾病体征或病史的年轻成年人的腹主动脉，用于组织形态计量学测量。
使用具有高分辨率成像和血流速度映射功能的磁共振技术，测量肾动脉上方和下方腹主动脉的壁面剪应力。在相同的腹主动脉位置，使用组织形态计量学技术盲目测量内膜厚度，并通过线性回归分析将其与壁面剪应力变量相关联。
内膜厚度与平均壁面剪应力（r = -0.90，p < 0.01）和最大壁面剪应力（r = -0.86，p < 0.01）呈线性下降。
正常腹主动脉的内膜厚度与平均、最大和振荡壁面剪应力相关。这些体内数据证实了先前的体外研究，表明低和振荡壁面剪应力是内膜增厚以及动脉粥样硬化早期发展的定位因素。
