Heilier Jean-François, Verougstraete Violaine, Nackers Fabienne, Tonglet René, Donnez Jacques, Lison Dominique
Industrial Toxicology and Occupational Medicine Unit, Faculty of Medicine, Université catholique de Louvain, 30.54 Clos Chapelle aux Champs, B-1200 Brussels, Belgium.
Toxicol Lett. 2004 Dec 1;154(1-2):89-93. doi: 10.1016/j.toxlet.2004.07.006.
Environmental chemicals with oestrogen-like activity are suspected aetiological factors of endometriosis. In animal experiments, cadmium was recently shown to possess oestrogen-like properties. In the frame of a case-control study designed to investigate environmental risk factors for endometriosis, we compared cadmium urinary excretion (CdU) and blood concentration in 59 patients with peritoneal endometriosis, deep endometriotic (adenomyotic) nodules of the recto-vaginal septum and controls. After standardisation for age (30 years) and smoking status, the mean levels of cadmium in urine were (geometric mean [geometric S.D.]) 0.25 [1.50], 0.29 [1.76] and 0.26 [1.46] microg/g creatinine, respectively. Cadmium concentrations in blood did not differ among the three groups. These data, therefore, do not support a role for cadmium in the onset or the growth of endometriosis or deep endometriotic (adenomyotic) nodules of the recto-vaginal septum.
具有雌激素样活性的环境化学物质被怀疑是子宫内膜异位症的病因。在动物实验中，最近发现镉具有雌激素样特性。在一项旨在调查子宫内膜异位症环境危险因素的病例对照研究中，我们比较了59例腹膜子宫内膜异位症患者、直肠阴道隔深部子宫内膜异位（腺肌病样）结节患者及对照组的尿镉排泄量（CdU）和血镉浓度。在对年龄（30岁）和吸烟状况进行标准化后，尿镉的平均水平（几何平均数[几何标准差]）分别为0.25 [1.50]、0.29 [1.76]和0.26 [1.46]微克/克肌酐。三组之间血镉浓度无差异。因此，这些数据不支持镉在子宫内膜异位症或直肠阴道隔深部子宫内膜异位（腺肌病样）结节的发生或生长中起作用。
