镉、铅与子宫内膜异位症
Cadmium, lead and endometriosis.
作者信息
Heilier J F, Donnez J, Verougstraete V, Donnez O, Grandjean F, Haufroid V, Nackers F, Lison D
机构信息
Industrial Toxicology and Occupational Medicine Unit, Faculty of Medicine, Université Catholique de Louvain, 30.54 Clos Chapelle aux Champs, 1200, Brussels, Belgium.
出版信息
Int Arch Occup Environ Health. 2006 Nov;80(2):149-53. doi: 10.1007/s00420-006-0114-7. Epub 2006 May 11.
OBJECTIVES
Cadmium (Cd) and lead (Pb) have been demonstrated to exert endocrine disrupting activities. Their possible role in endometriosis, an oestrogen-dependent disease, is unknown.
METHODS
We compared cadmium urinary excretion (CdU) and blood concentration of cadmium (CdB) and lead (PbB) in 119 patients with peritoneal endometriosis and/or deep endometriotic (adenomyotic) nodules of the rectovaginal septum and 25 controls.
RESULTS
The mean levels of cadmium in urine and blood did not differ among the groups. Women suffering from endometriotic diseases showed lower levels of PbB than controls.
CONCLUSIONS
These data do not support a role for cadmium in the onset or the growth of endometriotic diseases but suggest a possible relationship with lead.
目的
镉（Cd）和铅（Pb）已被证明具有内分泌干扰活性。它们在子宫内膜异位症（一种雌激素依赖性疾病）中可能发挥的作用尚不清楚。
方法
我们比较了119例患有腹膜子宫内膜异位症和/或直肠阴道隔深部子宫内膜异位（腺肌病样）结节的患者与25名对照者的尿镉排泄量（CdU）以及血液中镉（CdB）和铅（PbB）的浓度。
结果
各组之间尿液和血液中的镉平均水平没有差异。患有子宫内膜异位症的女性的PbB水平低于对照组。
结论
这些数据不支持镉在子宫内膜异位症发病或生长中起作用，但提示可能与铅有关。
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