[镰状细胞病患儿的遗尿症]

[Enuresis in children with sickle cell disease].

作者信息

Mabiala Babela J R, Loumingou R, Pemba-Loufoua A, Londjongo W, Nzingoula S, Senga P

机构信息

Service de pédiatrie, CHU de Brazzaville, BP 32, Congo.

出版信息

Arch Pediatr. 2004 Oct;11(10):1168-72. doi: 10.1016/j.arcped.2004.05.017.

DOI:10.1016/j.arcped.2004.05.017

PMID:15475271

Abstract

POPULATIONS AND METHODS

In order to analyze epidemiological and clinical characteristics of enuresis in children with sickle cell disease, and identify risk and aetiological factors, 987 subjects (aged 5-20 years) took part in a cross-sectional study. These children were divided into two groups: group 1 consisted of 456 homozygous children with sickle cell disease (haemoglobin SS), while group 2 consisted of 531 normal children. These groups were paired according to age and sex.

RESULTS

The prevalence of enuresis was 50.9% in group 1 and 16.4% in group 2, and was significantly higher (P < 0.05) in the girls. The frequency decreased significantly between the ages of 5-20. At age 16, frequency of enuretic children with sickle cell disease remained statistically greater (15.9% vs. 8.0%). The frequency of wet nights was higher (P < 0.05) in group 1. In addition, anaemia crisis and painful crisis were related to prevalence of enuresis. There was a significant (P < 0.01) negative correlation between haemoglobin F percentage and prevalence of enuresis.

CONCLUSION

Enuresis is frequent in children with sickle cell disease and its intensity is linked to severity of disease.

摘要

研究对象与方法

为分析镰状细胞病患儿遗尿症的流行病学和临床特征，并确定风险因素和病因，987名年龄在5至20岁的受试者参与了一项横断面研究。这些儿童被分为两组：第一组由456名镰状细胞病纯合子儿童（血红蛋白SS型）组成，而第二组由531名正常儿童组成。这两组根据年龄和性别进行配对。

结果

第一组遗尿症患病率为50.9%，第二组为16.4%，女孩患病率显著更高（P < 0.05）。5至20岁之间患病率显著下降。16岁时，镰状细胞病遗尿症患儿的患病率在统计学上仍更高（15.9%对8.0%）。第一组夜间尿床频率更高（P < 0.05）。此外，贫血危象和疼痛危象与遗尿症患病率相关。血红蛋白F百分比与遗尿症患病率之间存在显著负相关（P < 0.01）。