Miliaras Nicholas B, Wendland Beverly
Department of Biology, The Johns Hopkins University, Baltimore, MD 21218, USA.
Cell Biochem Biophys. 2004;41(2):295-318. doi: 10.1385/CBB:41:2:295.
Endocytosis is a protein and lipid-trafficking pathway that occurs in all eukaryotic cells. It involves the internalization of plasma membrane proteins and lipids into the cell and the subsequent degradation of proteins in the lysosome or the recycling of proteins and lipids back to the plasma membrane. Over the past decade, studies in yeast and mammalian cells have revealed endocytosis to be a very complex molecular process that depends on regulated interactions between a variety of proteins and lipids. The Eps15 homology (EH) domain is a conserved, modular protein-interaction domain found in several endocytosis proteins. EH proteins can function as key regulators of endocytosis through their ability to interact with many of the other proteins involved in this process.
内吞作用是一种在所有真核细胞中都存在的蛋白质和脂质运输途径。它涉及质膜蛋白和脂质内化进入细胞，以及随后蛋白质在溶酶体中的降解或蛋白质和脂质再循环回到质膜。在过去十年中，对酵母和哺乳动物细胞的研究表明，内吞作用是一个非常复杂的分子过程，它依赖于多种蛋白质和脂质之间的调控相互作用。Eps15同源（EH）结构域是在几种内吞作用蛋白中发现的一种保守的模块化蛋白质相互作用结构域。EH蛋白能够与参与这一过程的许多其他蛋白质相互作用，从而可作为内吞作用的关键调节因子发挥作用。
