Baldewicz Teri T, Leserman Jane, Silva Susan G, Petitto John M, Golden Robert N, Perkins Diana O, Barroso Julie, Evans Dwight L
Department of Clinical Operations, Inveresk, Cary, North Carolina, USA.
AIDS Behav. 2004 Sep;8(3):345-55. doi: 10.1023/B:AIBE.0000044081.42034.54.
Despite the advent of more effective treatments for HIV-1 infection, cognitive impairment is still frequent and questions remain regarding which areas of impairment are more common in the different disease stages. This study investigated cognitive performance over an 8-year period of time in 59 HIV-1 seropositive (HIV-1+) men who were clinically asymptomatic at study entry, in comparison to a cohort of 55 HIV-1 seronegative (HIV-1-) men. Every 6 months we examined cognitive functioning in 5 domains-fine motor speed, attention, verbal memory, executive functioning, and speed of information processing. We found that patients with AIDS scored significantly worse on fine motor speed and speed of information processing than HIV-1- individuals and the HIV-1+ non-AIDS patients. In addition, the HIV-1+ non-AIDS patients performed more poorly than the HIV-1- group on speed of information processing. Depressive symptoms were also associated with diminished performance on measures of attention, executive functioning, and speed of information processing. Further research is needed to examine the effects of disease stage and depression on cognitive impairment in the era of new HIV treatments.
尽管针对HIV-1感染出现了更有效的治疗方法，但认知障碍仍然很常见，而且在不同疾病阶段哪些受损领域更为常见仍存在疑问。本研究调查了59名在研究开始时临床无症状的HIV-1血清阳性（HIV-1+）男性在8年时间内的认知表现，并与55名HIV-1血清阴性（HIV-1-）男性组成的队列进行了比较。每6个月，我们在5个领域检查认知功能——精细运动速度、注意力、言语记忆、执行功能和信息处理速度。我们发现，艾滋病患者在精细运动速度和信息处理速度方面的得分明显低于HIV-1-个体和HIV-1+非艾滋病患者。此外，HIV-1+非艾滋病患者在信息处理速度方面的表现比HIV-1-组更差。抑郁症状也与注意力、执行功能和信息处理速度测量指标的表现下降有关。在新的HIV治疗时代，需要进一步研究来检查疾病阶段和抑郁对认知障碍的影响。
