Basso M R, Bornstein R A
University of Tulsa, OK 74104, USA.
J Clin Exp Neuropsychol. 2000 Feb;22(1):104-14. doi: 10.1076/1380-3395(200002)22:1;1-8;FT104.
Effects of immunosuppression and illness severity upon neuropsychological function were assessed in a group of homosexual men with AIDS across 6 months. Participants included 62 who were seronegative (HIV-), 74 asymptomatic seropositives (HIV+A), 31 symptomatic seropositives (HIV+S), 23 with AIDS defining illnesses (AIDS-DI), and 10 who were diagnosed with AIDS solely on the basis of CD4+ levels falling below 200 /mm3 (AIDS-CD4). Groups were equivalent in age, education, and IQ. None were drug users, and none experienced a change in disease status across the 6-month inter-test interval. There was little evidence of cognitive decline across time. Nonetheless, after collapsing across time intervals, the AIDS-DI group had worse new-learning than all other groups. Additionally, the AIDS-DI demonstrated a greater number of impaired performances than the other participant groups. The data suggest that cognitive impairment in AIDS is unlikely due to independent contributions of immunosuppression and illness. Rather neurobehavioral deficits are more likely attributable to a combination of the two.
在一组患有艾滋病的同性恋男性中，对免疫抑制和疾病严重程度对神经心理功能的影响进行了为期6个月的评估。参与者包括62名血清阴性者（HIV-）、74名无症状血清阳性者（HIV+A）、31名有症状血清阳性者（HIV+S）、23名患有艾滋病定义疾病者（AIDS-DI）以及10名仅根据CD4+水平降至200/mm3以下而被诊断为艾滋病者（AIDS-CD4）。各组在年龄、教育程度和智商方面相当。没有人是吸毒者，并且在6个月的测试间隔期间没有人的疾病状态发生变化。几乎没有证据表明随着时间推移认知能力会下降。尽管如此，在合并各个时间间隔的数据后，AIDS-DI组在新学习方面比所有其他组都差。此外，AIDS-DI组表现受损的数量比其他参与者组更多。数据表明，艾滋病中的认知障碍不太可能是免疫抑制和疾病单独作用的结果。相反，神经行为缺陷更可能归因于两者的综合作用。
