Voessing R, Berthold F, Richard K E, Thun F, Schroeder R, Krueger G R
Institut für Pathologie, Universität zu Köln, Germany.
Clin Neuropathol. 1992 Jan-Feb;11(1):11-5.
The first case of a pinealis region tumor of the hematopoietic system without known leukemia (so-called primary myeloblastoma, primary granulocytic sarcoma) is reported. Two weeks after resection, the 3.5-year-old patient suffered from a local recurrence. At this time, a bone marrow infiltration by leukemic blasts was diagnosed for the first time. An aggressive chemotherapy and radiation induced a complete remission, over a 26-month follow-up period. We examined the removed tumor tissue by routine histology methods, immuno- and enzyme histochemistry and electron microscopy. The CSF was studied by conventional microscopy and enzyme cytochemistry. We discuss the epidemiological data of nine previously published cases of primary intracranial myeloblastoma.
报告了首例无已知白血病的造血系统松果体区肿瘤（所谓的原发性成髓细胞瘤、原发性粒细胞肉瘤）。切除术后两周，这名3.5岁的患者出现局部复发。此时，首次诊断出白血病母细胞骨髓浸润。积极的化疗和放疗诱导了完全缓解，随访期为26个月。我们通过常规组织学方法、免疫和酶组织化学以及电子显微镜检查了切除的肿瘤组织。通过传统显微镜检查和酶细胞化学研究了脑脊液。我们讨论了先前发表的9例原发性颅内成髓细胞瘤病例的流行病学数据。
