Healey J H, Lane J M, Erlandson R A, Bullough P G
Clin Orthop Relat Res. 1985 Apr(194):248-51.
Granulocytic sarcoma of the clavicle occurred in a 17-year-old boy. The patient had a densely sclerotic bony lesion with periosteal reaction and no peripheral blood manifestations of leukemia. Supraclavicular adenopathy developed after a preliminary diagnosis of Ewing's sarcoma was made, and a second biopsy was performed. Electron microscopy of the tissue showed Auer bodies and Charcot-Leyden granules characteristic of acute myelogenous leukemia. Combination chemotherapy, local irradiation, and clavicular resection have left the patient with no evidence of disease 50 months after diagnosis. Leukemia may appear as a solitary bone tumor before hematologic changes develop. Granulocytic sarcomas can have the radiographic and histologic appearance of primary bone tumors. Bone marrow examination and electron microscopy of biopsy tissue are diagnostic of leukemia and are important in all hospital investigations of round-cell tumors of bone.
一名17岁男孩发生了锁骨粒细胞肉瘤。患者有一个致密硬化的骨病变并伴有骨膜反应，且无白血病的外周血表现。在初步诊断为尤因肉瘤后出现了锁骨上腺病，于是进行了第二次活检。组织的电子显微镜检查显示了急性髓性白血病特有的奥氏小体和夏科-莱登结晶。联合化疗、局部放疗和锁骨切除术使患者在诊断后50个月没有疾病迹象。白血病可能在血液学变化出现之前表现为孤立性骨肿瘤。粒细胞肉瘤可具有原发性骨肿瘤的影像学和组织学表现。骨髓检查和活检组织的电子显微镜检查对白血病具有诊断意义，并且在所有骨圆形细胞瘤的医院检查中都很重要。
