Wong I W Y, Omari T I, Myers J C, Rees G, Nair S B, Jamieson G G, Wormald P J
Department of Surgery--Otolaryngology, Head and Neck Surgery, Adelaide and Flinders Universities, South Australia.
Laryngoscope. 2004 Sep;114(9):1582-5. doi: 10.1097/00005537-200409000-00015.
To determine the prevalence of acid reflux into the nasopharynx in patients with chronic sinusitis.
Prospective study of patients presenting to a specialist rhinology practice with chronic sinusitis.
Forty patients with chronic sinusitis underwent ambulatory 24 hour pH testing. The mean age of the patients was 56.3 years (25 Female, 15 Male). The studies were performed using a specially developed bifurcated 4 channel pH probe, incorporating 2 circumferential sensors positioned at the naso- and hypo-pharynx, and 2 unidirectional sensors positioned at the proximal and distal esophagus.
The circumferential band sensors yielded a stable recording largely free of artefact allowing meaningful recordings to be obtained from thirty-seven patients. Twelve patients (32.4%) were diagnosed with gastroesophageal reflux. A total of 809 reflux episodes were recorded. Of these, 596 (73.7%) reached the distal esophagus, with 187 (23.1%) and 24 (3.0%) reaching the proximal esophagus and hypopharynx respectively. Only 2 episodes (0.2%) were recorded in the nasopharynx. This occurred in 2 of 37 patients (5%).
Acid reflux into the nasopharynx is a rare event in patients with chronic sinusitis even though a significant proportion (32.4%) have abnormal 24 hour pH studies. It is likely that alternative mechanisms other than direct acid contact are involved in the pathogenesis of chronic sinusitis.
确定慢性鼻窦炎患者鼻咽部酸反流的患病率。
对到专科鼻科门诊就诊的慢性鼻窦炎患者进行前瞻性研究。
40例慢性鼻窦炎患者接受了24小时动态pH检测。患者的平均年龄为56.3岁(女性25例,男性15例)。检测采用专门研发的分叉式四通道pH探头,其中包含2个圆周传感器,分别置于鼻咽部和下咽,以及2个单向传感器,分别置于食管近端和远端。
圆周带传感器记录稳定,基本无伪差,37例患者获得了有意义的记录。12例患者(32.4%)被诊断为胃食管反流。共记录到809次反流事件。其中,596次(73.7%)到达食管远端,187次(23.1%)和24次(3.0%)分别到达食管近端和下咽。仅2次事件(0.2%)记录于鼻咽部。这发生在37例患者中的2例(5%)。
尽管相当比例(32.4%)的慢性鼻窦炎患者24小时pH检测结果异常,但鼻咽部酸反流在慢性鼻窦炎患者中是罕见事件。慢性鼻窦炎的发病机制可能涉及除直接酸接触以外的其他机制。