Mahdavinia Mahboobeh, Bishehsari Faraz, Hayat Waqas, Codispoti Christopher D, Sarrafi Shahram, Husain Inna, Mehta Arpita, Benhammuda Mohamed, Tobin Mary C, Bandi Sindhura, LoSavio Philip S, Jeffe Jill S, Palmisano Erica L, Schleimer Robert P, Batra Pete S
Department of Immunology and Microbiology, Allergy/Immunology Section, Rush University Medical Center, Chicago, Illinois.
Division of Gastroenterology, Internal Medicine Department, Rush University Medical Center, Chicago, Illinois.
Ann Allergy Asthma Immunol. 2016 Aug;117(2):158-162.e1. doi: 10.1016/j.anai.2016.05.018. Epub 2016 Jun 7.
An association between chronic rhinosinusitis (CRS) and gastroesophageal reflux disease (GERD) has been previously reported; however, the underlying factors linking CRS and GERD remain to be elucidated.
To assess the association of GERD and CRS using prospective and retrospective approaches.
The retrospective study comprised a large cohort of CRS cases, whereas the prospective arm evaluated a series of CRS cases and controls.
In the retrospective arm of the study, of the 1066 patients with CRS, 112 (10.5%) had GERD. Among patients with CRS, GERD was associated with higher body mass index, older age, and female sex. The odds ratios (ORs) for asthma and allergic rhinitis in the CRS group with GERD compared with the CRS group without GERD were 2.89 (95% confidence interval [CI], 1.905-4.389) and 2.021 (95% CI, 1.035-3.947). Furthermore, GERD was associated with a greater duration of CRS. Ninety patients with CRS and 81 controls were enrolled in the prospective arm of the study. In the CRS group, GERD was associated with asthma (OR, 4.77; 95% CI, 1.27-18.01). Patients with CRS and GERD had a longer duration and a younger age at onset of CRS. In controls, no association was found between GERD and asthma (OR, 0.67; 95% CI, 0.09-5.19) or allergic rhinitis (OR, 0.35; 95% CI, 0.05-2.59).
Patients with CRS and GERD are more likely to have atopic conditions and asthma when compared with patients with CRS but without GERD. One of the potential explanations of this link is that comorbid GERD and atopic disease are potential risk factors for development of CRS.
先前已有慢性鼻-鼻窦炎（CRS）与胃食管反流病（GERD）之间存在关联的报道；然而，将CRS与GERD联系起来的潜在因素仍有待阐明。
采用前瞻性和回顾性方法评估GERD与CRS之间的关联。
回顾性研究纳入了一大群CRS病例，而前瞻性研究则评估了一系列CRS病例和对照。
在该研究的回顾性研究部分，1066例CRS患者中，112例（10.5%）患有GERD。在CRS患者中，GERD与较高的体重指数、年龄较大以及女性性别相关。与无GERD的CRS组相比，有GERD的CRS组中哮喘和变应性鼻炎的比值比（OR）分别为2.89（95%置信区间[CI]，1.905 - 4.389）和2.021（95%CI，1.035 - 3.947）。此外，GERD与CRS的病程更长有关。该研究的前瞻性研究部分纳入了90例CRS患者和81例对照。在CRS组中，GERD与哮喘相关（OR，4.77；95%CI，1.27 - 18.01）。患有CRS和GERD的患者CRS病程更长且发病年龄更小。在对照组中，未发现GERD与哮喘（OR，0.67；95%CI，0.09 - 5.19）或变应性鼻炎（OR，0.35；95%CI，0.05 - 2.59）之间存在关联。
与无GERD的CRS患者相比，患有CRS和GERD的患者更易患特应性疾病和哮喘。这种联系的一个潜在解释是，GERD和特应性疾病共病是CRS发生发展的潜在危险因素。
