Economou Emanuel V, Malamitsi-Puchner Ariadne V, Pitsavos Christos P, Kouskouni Evangelia E, Magaziotou-Elefsinioti Ioanna, Damianaki-Uranou Despina, Stefanadis Christodoulos I, Creatsas Georgios
2 Clinic for Obstetrics and Gynecology, University of Athens, Aretaieion Hospital, Athens, Greece.
J Cardiovasc Pharmacol. 2004 Sep;44(3):310-5. doi: 10.1097/01.fjc.0000133587.01718.59.
This study investigated in prepubertal obese children (POC), compared with prepubertal lean children (PLC), a possible relation among plasma total homocysteine (tHcy)-an independent risk factor for future atherosclerosis-and MCP-1 and RANTES, two circulating chemokines inducing leukocyte transendothelial migration (TEM), implicated in the initial stages of the inflammatory part of the atherosclerotic process. Seventy-two POC were evaluated for circulating tHcy, MCP-1, and RANTES, and compared with 42 healthy PLC. The mean adjusted (for age, sex as well as log10total insulin, vitB12, folate, total cholesterol, HDL cholesterol, log10triglycerides, and log10glucose levels) differences in tHcy, MCP-1, and RANTES levels between PLC and POC were all significant [1.16 nmol/mL (P = 0.03), 26.6 pg/mL (P = 0.02), and 52.9 pg/mL (P = 0.03), respectively]. In PLC, but not in POC, tHcy levels were negatively associated with both circulating MCP-1 (B = -1.68, P = 0.007) and RANTES (B = -1.16, P = 0.01) after adjusting for age, sex, BMI, as well as log10total insulin, vitB12, folate, total cholesterol, HDL cholesterol, log10triglycerides, and log10glucose levels. In conclusion, in POC there is a lack, in contrast to PLC, of a possibly autoregulatory, negative association of elevated tHcy levels to increased MCP-1 and RANTES levels. This could contribute to future, homocysteine-induced atherosclerosis.
本研究调查了青春期前肥胖儿童（POC），并与青春期前瘦儿童（PLC）进行比较，探讨血浆总同型半胱氨酸（tHcy）（未来动脉粥样硬化的独立危险因素）与MCP-1和RANTES之间的可能关系，这两种循环趋化因子可诱导白细胞跨内皮迁移（TEM），参与动脉粥样硬化炎症过程的初始阶段。对72名POC的循环tHcy、MCP-1和RANTES进行了评估，并与42名健康PLC进行比较。PLC和POC之间，经年龄、性别以及log10总胰岛素、维生素B12、叶酸、总胆固醇、高密度脂蛋白胆固醇、log10甘油三酯和log10血糖水平校正后，tHcy、MCP-1和RANTES水平的平均差异均具有显著性[分别为1.16 nmol/mL（P = 0.03）、26.6 pg/mL（P = 0.02）和52.9 pg/mL（P = 0.03）]。在PLC中，而非POC中，经年龄、性别、BMI以及log10总胰岛素、维生素B12、叶酸、总胆固醇、高密度脂蛋白胆固醇、log10甘油三酯和log10血糖水平校正后，tHcy水平与循环MCP-1（B = -1.68，P = 0.007）和RANTES（B = -1.16，P = 0.01）均呈负相关。总之，与PLC相比，POC中升高的tHcy水平与升高的MCP-1和RANTES水平之间缺乏可能的自动调节负相关。这可能会导致未来同型半胱氨酸诱导的动脉粥样硬化。
