Economou Emanuel V, Malamitsi-Puchner Ariadne V, Pitsavos Christos P, Kouskouni Evangelia E, Magaziotou-Elefsinioti Ioanna, Creatsas George
Hormone Laboratory, 2nd Clinic for Obstetrics and Gynecology, Aretaieon Hospital, University of Athens, Greece.
Mediators Inflamm. 2005 Dec 14;2005(6):337-42. doi: 10.1155/MI.2005.337.
To investigate in prepubertal obese children (POC) the profile of chronic low-grade systemic inflammation (CLGSI) and its relation to homocysteinemia, 72 POC were evaluated for serum C-reactive protein (CRP) and amyloid A (SAA) levels, both markers of CLGSI, and plasma levels of total homocysteine (tHcy), an independent risk factor for adult atherosclerosis, in comparison to 42 prepubertal lean children (PLC). The main observations in POC were higher CRP levels compared to PLC, positive association of SAA levels to CRP levels, no association of CRP or SAA levels to tHcy levels. Thus, in POC, positively interrelated to each other, elevated CRP and unaltered SAA levels reveal a unique profile of the CLGSI, not explaining homocysteinemia-induced risk for future atherosclerosis.
为了研究青春期前肥胖儿童（POC）的慢性低度全身炎症（CLGSI）特征及其与高同型半胱氨酸血症的关系，我们评估了72名POC的血清C反应蛋白（CRP）和淀粉样蛋白A（SAA）水平（二者均为CLGSI的标志物）以及总同型半胱氨酸（tHcy）的血浆水平（成人动脉粥样硬化的独立危险因素），并与42名青春期前瘦儿童（PLC）进行了比较。POC的主要观察结果为：与PLC相比，CRP水平更高；SAA水平与CRP水平呈正相关；CRP或SAA水平与tHcy水平无关联。因此，在POC中，CRP升高和SAA水平未改变相互之间呈正相关，揭示了CLGSI的独特特征，无法解释高同型半胱氨酸血症所致的未来动脉粥样硬化风险。
