D'Athis F, Lauret F
Ann Anesthesiol Fr. 1976;17(11):1229-37.
The authors report on 50 surgical or endoscopic cases in which local or regional anaesthesia was completed with a combination of diazepam and pentazocine (Pentazapam). This "diazanalgesia" was performed either as a routine or as a complement to regional anaesthesia (mostly an epidural) in which restlessness or insufficient analgesia were noted. Both drugs are injected separately. Diazepam being used to combat anxiety and pentazocine to allay pain. Sedation was considered to be sufficient in 43 cases out of 50 and analgesia in 47 cases out of 50. In all but one case, recovery was calm. In 24 cases, the patients regained consciensness quickly. There was only little effect on respiratory frequency, blood gases, blood pressure or cardiac rate. Thus, pentazepam combination can be considered as a useful method of "wake diazanalgesia" as far as it is used to complement a local or regional anaesthesia. This technique seems particularly useful in the aged or bad risk patient because of its moderate cardiovascular or respiratory aciton.
作者报告了50例手术或内镜检查病例，这些病例采用地西泮和喷他佐辛（戊唑酰胺）联合进行局部或区域麻醉。这种“安定镇痛法”要么作为常规方法，要么作为区域麻醉（主要是硬膜外麻醉）的补充，用于处理出现的躁动或镇痛不足情况。两种药物分别注射，地西泮用于对抗焦虑，喷他佐辛用于减轻疼痛。50例中有43例镇静效果充分，50例中有47例镇痛效果良好。除1例外，所有病例恢复过程平稳。24例患者苏醒迅速。对呼吸频率、血气、血压或心率影响极小。因此，就用于补充局部或区域麻醉而言，戊唑酰胺联合用药可被视为一种有用的“清醒安定镇痛”方法。由于其中等的心血管或呼吸作用，该技术在老年或高危患者中似乎特别有用。
