Graham J L, McCaughey W, Bell P F
Craigavon Area Hospital, Co. Armagh.
Ann R Coll Surg Engl. 1988 Jul;70(4):200-4.
Sedation by a combination of an opioid drug such as pentazocine with a benzodiazepine is commonly used for minor surgical and investigative procedures. Nalbuphine is a newer drug which, like pentazocine, is an opioid agonist-antagonist. Its actions are similar, but it has theoretical advantages in its profile of cardiovascular side effects. Nalbuphine or pentazocine in combination with diazepam were compared as components of a sedative technique for invasive radiology. The doses used were in the ratio of 2.5:1--ie nalbuphine 0.2 mg kg-1 and pentazocine 0.5 mg kg-1. Both regimens gave satisfactory results, and no difference could be detected between them in terms of sedation, analgesic efficacy, cardiovascular or respiratory changes, or recovery. Nalbuphine provides a safe and effective alternative to pentazocine in this situation. The study confirmed the need for caution because of the respiratory depressant effects of both drugs.
将阿片类药物如喷他佐辛与苯二氮䓬类药物联合使用进行镇静，常用于小型外科手术和检查程序。纳布啡是一种较新的药物，与喷他佐辛一样，是一种阿片受体激动-拮抗剂。它的作用相似，但在心血管副作用方面具有理论优势。将纳布啡或喷他佐辛与地西泮联合使用作为侵入性放射学镇静技术的组成部分进行了比较。所用剂量比例为2.5:1，即纳布啡0.2mg/kg和喷他佐辛0.5mg/kg。两种方案均取得了满意的结果，在镇静、镇痛效果、心血管或呼吸变化以及恢复方面均未发现两者之间存在差异。在这种情况下，纳布啡是喷他佐辛的一种安全有效的替代药物。该研究证实了由于两种药物都有呼吸抑制作用，因此需要谨慎使用。
