Snelling Carolyn M H, Poenaru Dan, Drover John W
Queen's University School of Medicine, Kingston, Ontario, Canada.
Pediatr Surg Int. 2004 Dec;20(11-12):838-45. doi: 10.1007/s00383-004-1280-x. Epub 2004 Oct 6.
The suitable duration of antibiotic use following appendectomy for advanced appendicitis in children is still debated. A systematic review was performed, including published experimental and observational data of antibiotic use in children who had undergone appendectomy for advanced appendicitis. Data were extracted and analyzed according to predefined criteria. Twenty-eight studies were selected that included 2,284 patients. There was no consistency among the protocols regarding length of antibiotic use, discharge criteria, or use of home antibiotics following discharge. Limiting duration of antibiotic use to 3 days did not appear to be associated with higher rates of intraabdominal abscess or wound infection. In the absence of higher-level evidence, shortening of antibiotic regimens following surgery for pediatric complicated appendicitis appears to be safe.
儿童复杂性阑尾炎阑尾切除术后抗生素的适宜使用时长仍存在争议。我们进行了一项系统综述，纳入已发表的关于儿童复杂性阑尾炎阑尾切除术后抗生素使用的实验性和观察性数据。根据预先设定的标准提取并分析数据。共筛选出28项研究，涉及2284例患者。在抗生素使用时长、出院标准或出院后家庭抗生素使用方面，各方案之间没有一致性。将抗生素使用时长限制在3天似乎与腹腔内脓肿或伤口感染率升高无关。在缺乏更高级别证据的情况下，小儿复杂性阑尾炎手术后缩短抗生素治疗方案似乎是安全的。
