Geissinger Eva, Odenwald Tobias, Lee Seung-Sook, Bonzheim Irina, Roth Sabine, Reimer Peter, Wilhelm Martin, Müller-Hermelink Hans Konrad, Rüdiger Thomas
Institute of Pathology, University of Würzburg, Josef-Schneider-Strasse 2, 97080 Würzburg, Germany.
Virchows Arch. 2004 Oct;445(4):334-43. doi: 10.1007/s00428-004-1077-2. Epub 2004 Jul 29.
Nodal peripheral T-cell lymphomas are not well understood, and most of them are classified in the "not otherwise specified group" (PTCL-NOS). Data on their normal cellular derivation are ambiguous. Most peripheral T-cell lymphomas are composed of tumor cells and a (sometimes dominant) reactive background, which also includes resting and activated T-lymphocytes. We defined the phenotype of the tumor cells in 101 PTCL-NOS based on their cytological atypia and using immunohistochemical double stains on paraffin sections with CD4/Ki67 and CD8/Ki67. The results were correlated to clinical presentation and outcome. Lineage could be defined in 98 cases (97%). Tumor cells were CD4(+) in 43 cases and CD8(+) in 38. These presented at a younger age but a higher clinical stage compared with the CD4(+) lymphomas. In 15 cases, the atypical cells were CD4(-)CD8(-); two cases were CD4(+)CD8(+). Of 17 lymphoepithelioid (Lennert's) lymphomas, 15 expressed CD8, one each was CD4(+) and CD4(-)CD8(-).
结外外周T细胞淋巴瘤尚未被充分了解，其中大多数被归类于“其他未特指组”（PTCL-NOS）。关于它们正常细胞起源的数据尚不明确。大多数外周T细胞淋巴瘤由肿瘤细胞和一个（有时占主导）反应性背景组成，该背景还包括静止和活化的T淋巴细胞。我们基于101例PTCL-NOS肿瘤细胞的细胞学异型性，并使用CD4/Ki67和CD8/Ki67对石蜡切片进行免疫组化双重染色，来定义其肿瘤细胞的表型。结果与临床表现和预后相关。98例（97%）病例的谱系得以确定。43例肿瘤细胞为CD4(+)，38例为CD8(+)。与CD4(+)淋巴瘤相比，这些病例发病年龄较轻，但临床分期较高。15例中，非典型细胞为CD4(-)CD8(-)；2例为CD4(+)CD8(+)。在17例淋巴上皮样（ Lennert型）淋巴瘤中，15例表达CD8，1例为CD4(+)，1例为CD4(-)CD8(-)。
