Feller A C, Griesser G H, Mak T W, Lennert K
Blood. 1986 Sep;68(3):663-7.
Lymphoepithelioid lymphoma (Lennert's lymphoma) was first described as a special variant of Hodgkin's disease. This lesion is characterized by a high percentage of epithelioid and T cells and rarely contains the classical Hodgkin's/Reed-Sternberg cells. Cytogenetic abnormalities indicate that Lennert's lymphoma is of T cell origin. In the present study, immunohistochemical investigation of four cases of Lennert's lymphoma revealed two major cell populations of T cells that predominantly express the helper-inducer phenotype and Ki-M6- and Ki-M8-positive macrophages and epithelioid cells. Double-staining experiments for the detection of cell surface antigens and the proliferation-associated antigen Ki67 showed that only the CD4-positive cells (helper-inducer T cells) were proliferating. Examination of the DNA of these Lennert's lymphoma samples also indicated that monoclonal rearrangement of the T cell receptor beta-chain genes has occurred, whereas the immunoglobulin heavy- and kappa-chain genes remained in germline configuration. Our results strongly suggest that Lennert's lymphoma is a CD4-positive T cell lymphoma.
淋巴上皮样淋巴瘤（ Lennert淋巴瘤）最初被描述为霍奇金病的一种特殊变体。该病变的特征是上皮样细胞和T细胞比例高，很少含有经典的霍奇金/里德-斯腾伯格细胞。细胞遗传学异常表明Lennert淋巴瘤起源于T细胞。在本研究中，对4例Lennert淋巴瘤进行免疫组化研究发现，主要有两种T细胞亚群，它们主要表达辅助诱导表型以及Ki-M6和Ki-M8阳性巨噬细胞和上皮样细胞。检测细胞表面抗原和增殖相关抗原Ki67的双重染色实验表明，只有CD4阳性细胞（辅助诱导T细胞）在增殖。对这些Lennert淋巴瘤样本的DNA检测还表明，T细胞受体β链基因发生了单克隆重排，而免疫球蛋白重链和κ链基因仍处于种系构型。我们的结果强烈提示Lennert淋巴瘤是一种CD4阳性T细胞淋巴瘤。
