猪对致死性肺炎球菌败血症的抵抗力与血液中白细胞介素-6水平降低有关。
Protection against lethal pneumococcal septicemia in pigs is associated with decreased levels of interleukin-6 in blood.
作者信息
Ziegler-Heitbrock H W, Passlick B, Käfferlein E, Coulie P G, Izbicki J R
机构信息
Institute for Immunology, Munich, Germany.
出版信息
Infect Immun. 1992 Apr;60(4):1692-4. doi: 10.1128/iai.60.4.1692-1694.1992.
Abstract
Injection of type 6b pneumococci into pigs results in a sharp rise in levels of interleukin-6 (IL-6) in blood, with an average peak value of 7,700 U/ml at 4 h and mortality in five of seven of these animals. Pretreatment at -24 h with the monocyte activator MTP-PE prevents this strong increase in IL-6 (peak value, 1,000 U/ml) and reduces mortality to zero of six animals. This suggests that MTP-PE, in addition to activating monocytes, protects animals by preventing the harmful increase of cytokines such as IL-6.
摘要
将6b型肺炎球菌注射到猪体内会导致血液中白细胞介素-6（IL-6）水平急剧上升，4小时时平均峰值为7700 U/ml，这些动物中有7只死亡5只。在-24小时用单核细胞激活剂MTP-PE进行预处理可防止IL-6的这种强烈升高（峰值为1000 U/ml），并将6只动物的死亡率降至零。这表明MTP-PE除了激活单核细胞外，还通过防止细胞因子如IL-6的有害增加来保护动物。
相似文献
1
Protection against lethal pneumococcal septicemia in pigs is associated with decreased levels of interleukin-6 in blood.猪对致死性肺炎球菌败血症的抵抗力与血液中白细胞介素-6水平降低有关。
Infect Immun. 1992 Apr;60(4):1692-4. doi: 10.1128/iai.60.4.1692-1694.1992.
2
3
Prevention of experimental endotoxin shock by a monocyte activator.一种单核细胞激活剂对实验性内毒素休克的预防作用
Antimicrob Agents Chemother. 1995 Nov;39(11):2535-40. doi: 10.1128/AAC.39.11.2535.
4
In vitro and in vivo production of interleukin-6 induced by muramyl peptides and lipopolysaccharide in normal dogs.在正常犬体内外，胞壁酰肽和脂多糖诱导白细胞介素-6的产生
Cancer Biother. 1995 Winter;10(4):317-25. doi: 10.1089/cbr.1995.10.317.
5
Muramyl tripeptide phosphatidylethanolamine encapsulated in liposomes stimulates monocyte production of tumor necrosis factor and interleukin-1 in vitro.包裹在脂质体中的胞壁酰三肽磷脂酰乙醇胺在体外刺激单核细胞产生肿瘤坏死因子和白细胞介素-1。
Cancer Commun. 1991;3(10-11):313-21. doi: 10.3727/095535491820873740.
6
Liposome-encapsulated MTP-PE: a novel biologic agent for cancer therapy.脂质体包裹的MTP-PE：一种用于癌症治疗的新型生物制剂。
J Immunother Emphasis Tumor Immunol. 1993 Nov;14(4):286-92. doi: 10.1097/00002371-199311000-00006.
7
Effect of ibuprofen on monocyte activation by liposome-encapsulated muramyl tripeptide phosphatidylethanolamine (CGP 19835A): can ibuprofen reduce fever and chills without compromising immune stimulation?布洛芬对脂质体包裹的胞壁酰三肽磷脂酰乙醇胺（CGP 19835A）激活单核细胞的影响：布洛芬能否在不损害免疫刺激的情况下减轻发热和寒战？
Cancer Immunol Immunother. 1993;36(1):45-51. doi: 10.1007/BF01789130.
8
Biologic therapy for osteosarcoma using liposome-encapsulated muramyl tripeptide.使用脂质体包裹的胞壁酰三肽治疗骨肉瘤的生物疗法。
Hematol Oncol Clin North Am. 1995 Aug;9(4):927-38.
9
10
Liposome-encapsulated muramyl tripeptide up-regulates monocyte chemotactic and activating factor gene expression in human monocytes at the transcriptional and post-transcriptional levels.脂质体包裹的胞壁酰三肽在转录和转录后水平上调人单核细胞中单核细胞趋化和激活因子基因的表达。
Cancer Immunol Immunother. 1994 Jan;38(1):16-22. doi: 10.1007/BF01517165.
引用本文的文献
1
Analysis of Porcine Pro- and Anti-Inflammatory Cytokine Induction by In Vivo and In Vitro.体内和体外诱导猪促炎和抗炎细胞因子的分析
Pathogens. 2020 Jan 3;9(1):40. doi: 10.3390/pathogens9010040.
2
Role of inflammatory mediators in resistance and susceptibility to pneumococcal infection.炎症介质在肺炎球菌感染的抵抗力和易感性中的作用。
Infect Immun. 2002 Mar;70(3):1547-57. doi: 10.1128/IAI.70.3.1547-1557.2002.
3
Prostaglandin E2 affects differently the release of inflammatory mediators from resident macrophages by LPS and muramyl tripeptides.前列腺素E2对脂多糖和胞壁酰三肽诱导的驻留巨噬细胞释放炎症介质有不同影响。
Mediators Inflamm. 1999;8(6):295-303. doi: 10.1080/09629359990306.
4
Prevention of experimental endotoxin shock by a monocyte activator.一种单核细胞激活剂对实验性内毒素休克的预防作用
Antimicrob Agents Chemother. 1995 Nov;39(11):2535-40. doi: 10.1128/AAC.39.11.2535.
5
Interleukin-6 production in a murine model of Pneumocystis carinii pneumonia: relation to resistance and inflammatory response.卡氏肺孢子虫肺炎小鼠模型中白细胞介素-6的产生：与抵抗力及炎症反应的关系
Infect Immun. 1993 Jan;61(1):97-102. doi: 10.1128/iai.61.1.97-102.1993.
6
Pneumolysin stimulates production of tumor necrosis factor alpha and interleukin-1 beta by human mononuclear phagocytes.肺炎溶素可刺激人单核吞噬细胞产生肿瘤坏死因子α和白细胞介素-1β。
Infect Immun. 1994 Apr;62(4):1501-3. doi: 10.1128/iai.62.4.1501-1503.1994.
7
The pneumococcus: host-organism interactions and their implications for immunotherapy and immunoprophylaxis.肺炎链球菌：宿主与病原体的相互作用及其对免疫治疗和免疫预防的意义。
Thorax. 1994 Oct;49(10):946-50. doi: 10.1136/thx.49.10.946.
8
A pneumolysin-negative mutant of Streptococcus pneumoniae causes chronic bacteremia rather than acute sepsis in mice.肺炎链球菌的一种肺炎溶血素阴性突变体在小鼠中引起慢性菌血症而非急性败血症。
Infect Immun. 1995 Feb;63(2):448-55. doi: 10.1128/iai.63.2.448-455.1995.
本文引用的文献
1
[Septicemia. Etiology, epidemiology, clinical aspects and prognosis in 446 patients].
Dtsch Med Wochenschr. 1983 Dec 16;108(50):1908-14. doi: 10.1055/s-2008-1069849.
2
Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin.针对恶病质素/肿瘤坏死因子的被动免疫可保护小鼠免受内毒素的致死作用。
Science. 1985 Aug 30;229(4716):869-71. doi: 10.1126/science.3895437.
3
Shock and tissue injury induced by recombinant human cachectin.重组人恶病质素诱导的休克和组织损伤
Science. 1986 Oct 24;234(4775):470-4. doi: 10.1126/science.3764421.
4
Nosocomial infections in a respiratory intensive care unit.呼吸重症监护病房的医院感染
Crit Care Med. 1987 May;15(5):495-8. doi: 10.1097/00003246-198705000-00008.
5
A controlled clinical trial of high-dose methylprednisolone in the treatment of severe sepsis and septic shock.大剂量甲泼尼龙治疗严重脓毒症和脓毒性休克的对照临床试验。
N Engl J Med. 1987 Sep 10;317(11):653-8. doi: 10.1056/NEJM198709103171101.
6
Purification and NH2-terminal amino acid sequence of a T-cell-derived lymphokine with growth factor activity for B-cell hybridomas.一种对B细胞杂交瘤具有生长因子活性的T细胞衍生淋巴因子的纯化及氨基末端氨基酸序列分析
Proc Natl Acad Sci U S A. 1986 Dec;83(24):9679-83. doi: 10.1073/pnas.83.24.9679.
7
Association between tumour necrosis factor in serum and fatal outcome in patients with meningococcal disease.血清肿瘤坏死因子与脑膜炎球菌病患者的致命结局之间的关联。
Lancet. 1987 Feb 14;1(8529):355-7. doi: 10.1016/s0140-6736(87)91728-4.
8
Mouse plasmacytoma growth in vivo: enhancement by interleukin 6 (IL-6) and inhibition by antibodies directed against IL-6 or its receptor.小鼠浆细胞瘤在体内的生长：白细胞介素6（IL-6）的促进作用以及抗IL-6或其受体抗体的抑制作用。
J Exp Med. 1990 Sep 1;172(3):997-1000. doi: 10.1084/jem.172.3.997.
9
Interleukin-6 induction by a muramyltripeptide derivative in cancer patients.癌症患者中一种胞壁酰三肽衍生物诱导白细胞介素-6的产生
J Biol Response Mod. 1990 Apr;9(2):160-6.
10
Adaptation to bacterial lipopolysaccharide controls lipopolysaccharide-induced tumor necrosis factor production in rabbit macrophages.对细菌脂多糖的适应性控制兔巨噬细胞中脂多糖诱导的肿瘤坏死因子产生。
J Clin Invest. 1990 Apr;85(4):1108-18. doi: 10.1172/JCI114542.
Zotero 插件