血清肿瘤坏死因子与脑膜炎球菌病患者的致命结局之间的关联。
Association between tumour necrosis factor in serum and fatal outcome in patients with meningococcal disease.
作者信息
Waage A, Halstensen A, Espevik T
出版信息
Lancet. 1987 Feb 14;1(8529):355-7. doi: 10.1016/s0140-6736(87)91728-4.
PMID:2880163
Abstract
Serum samples taken on admission from 79 patients with meningococcal meningitis, septicaemia, or both, were examined in a highly sensitive bioassay for tumour necrosis factor (TNF). TNF was detected in samples from 10 of 11 patients who died but from only 8 of 68 survivors. All 5 patients with serum TNF levels over 440 units/ml (corresponding to 0.1 ng/ml recombinant TNF) died.
摘要
对79例患有脑膜炎球菌性脑膜炎、败血症或两者皆有的患者入院时采集的血清样本进行了高灵敏度的肿瘤坏死因子（TNF）生物测定。在11例死亡患者的样本中检测到了TNF，但在68例幸存者中仅8例检测到。血清TNF水平超过440单位/毫升（相当于0.1纳克/毫升重组TNF）的所有5例患者均死亡。
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