肺炎溶素可刺激人单核吞噬细胞产生肿瘤坏死因子α和白细胞介素-1β。
Pneumolysin stimulates production of tumor necrosis factor alpha and interleukin-1 beta by human mononuclear phagocytes.
作者信息
Houldsworth S, Andrew P W, Mitchell T J
机构信息
Department of Microbiology and Immunology, University of Leicester, United Kingdom.
出版信息
Infect Immun. 1994 Apr;62(4):1501-3. doi: 10.1128/iai.62.4.1501-1503.1994.
Abstract
Human peripheral blood monocytes and a human monocyte cell line were exposed to the toxin pneumolysin. Pneumolysin-exposed cells produced significantly larger amounts of tumor necrosis factor alpha and interleukin-1 beta than cells not exposed to the toxin. The viability of cells was not affected by the concentrations of pneumolysin used in the experiments.
摘要
将人外周血单核细胞和一种人单核细胞系暴露于毒素肺炎溶血素中。与未暴露于该毒素的细胞相比，暴露于肺炎溶血素的细胞产生的肿瘤坏死因子α和白细胞介素-1β的量显著更多。实验中所用肺炎溶血素的浓度对细胞活力没有影响。
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