溶组织内阿米巴表面抗原对细菌的应答调节
Modulation of a surface antigen of Entamoeba histolytica in response to bacteria.
作者信息
Bhattacharya A, Ghildyal R, Prasad J, Bhattacharya S, Diamond L S
机构信息
School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
出版信息
Infect Immun. 1992 Apr;60(4):1711-3. doi: 10.1128/iai.60.4.1711-1713.1992.
Abstract
Changes in the cell surface of Entamoeba histolytica, a human intestinal parasite and the causative agent of amebic dysentery, were examined with a monoclonal antibody, 2D7.10, which selectively recognizes carbohydrate epitopes in some axenic amebic strains. While high-level expression of this epitope was observed in axenic amebae, it was either absent or present only in small amounts in xenic amebae. Furthermore, reassociation of the axenic amebae with intestinal flora resulted in loss of the 2D7.10 epitope. Our data suggest that surface antigens of E. histolytica can be modulated in response to bacteria and may provide an explanation for the observed influence of bacteria on amebic virulence.
摘要
对溶组织内阿米巴（一种人类肠道寄生虫及阿米巴痢疾的病原体）的细胞表面变化进行了研究，使用单克隆抗体2D7.10，该抗体可选择性识别某些无菌培养的阿米巴菌株中的碳水化合物表位。虽然在无菌培养的阿米巴中观察到该表位的高水平表达，但在有菌培养的阿米巴中要么不存在，要么仅少量存在。此外，无菌培养的阿米巴与肠道菌群重新结合导致2D7.10表位丧失。我们的数据表明，溶组织内阿米巴的表面抗原可因细菌而发生调节，这可能为观察到的细菌对阿米巴毒力的影响提供一种解释。
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