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本文引用的文献

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Immunobiologically active lipid A analogs synthesized according to a revised structural model of natural lipid A.根据天然脂质A的修订结构模型合成的具有免疫生物学活性的脂质A类似物。
Infect Immun. 1984 Jul;45(1):293-6. doi: 10.1128/iai.45.1.293-296.1984.
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Biological activities of analogues of lipid A based chemically on the revised structural model. Comparison of mediator-inducing, immunomodulating and endotoxic activities.基于修订结构模型的化学合成脂多糖A类似物的生物活性。介质诱导、免疫调节和内毒素活性的比较。
Eur J Biochem. 1984 Sep 3;143(2):237-42. doi: 10.1111/j.1432-1033.1984.tb08364.x.
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New Salmonella typhimurium mutants with altered outer membrane permeability.具有改变的外膜通透性的新型鼠伤寒沙门氏菌突变体。
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A new method for the extraction of R lipopolysaccharides.一种提取R脂多糖的新方法。
Eur J Biochem. 1969 Jun;9(2):245-9. doi: 10.1111/j.1432-1033.1969.tb00601.x.
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Extended deletions in the histidine-rough-B region of the Salmonella chromosome.沙门氏菌染色体组氨酸粗糙 -B 区域的延伸缺失
Proc Natl Acad Sci U S A. 1967 Jun;57(6):1825-32. doi: 10.1073/pnas.57.6.1825.
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Mouse virulence of Salmonella strains: the effect of different smooth-type O side-chains.沙门氏菌菌株的小鼠毒力：不同光滑型O侧链的影响。
J Gen Microbiol. 1970 Dec;64(3):255-68. doi: 10.1099/00221287-64-3-255.
7
Synthetic lipid A with endotoxic and related biological activities comparable to those of a natural lipid A from an Escherichia coli re-mutant.具有与来自大肠杆菌回复突变体的天然脂多糖A相当的内毒素及相关生物活性的合成脂多糖A。
Infect Immun. 1985 Jul;49(1):225-37. doi: 10.1128/iai.49.1.225-237.1985.
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Endotoxic properties of synthetic pentaacyl lipid A precursor Ib and a structural isomer.
Eur J Biochem. 1987 Nov 16;169(1):27-31. doi: 10.1111/j.1432-1033.1987.tb13576.x.
9
Importance of fatty acid substituents of chemically synthesized lipid A-subunit analogs in the expression of immunopharmacological activity.化学合成脂质A亚基类似物的脂肪酸取代基在免疫药理活性表达中的重要性。
Infect Immun. 1988 Jan;56(1):149-55. doi: 10.1128/iai.56.1.149-155.1988.
10
Structural characterization of the lipid A component of Bacteroides fragilis strain NCTC 9343 lipopolysaccharide.脆弱拟杆菌菌株NCTC 9343脂多糖的脂质A成分的结构表征
Eur J Biochem. 1989 Aug 1;183(2):425-31. doi: 10.1111/j.1432-1033.1989.tb14945.x.

幽门螺杆菌脂多糖的生物活性较低。

Low biological activity of Helicobacter pylori lipopolysaccharide.

作者信息

Muotiala A, Helander I M, Pyhälä L, Kosunen T U, Moran A P

机构信息

Department of Bacteriology, National Public Health Institute, Helsinki, Finland.

出版信息

Infect Immun. 1992 Apr;60(4):1714-6. doi: 10.1128/iai.60.4.1714-1716.1992.

DOI:10.1128/iai.60.4.1714-1716.1992
PMID:1548097
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC257055/
Abstract

Lipopolysaccharide from the gastroduodenal pathogen Helicobacter pylori was tested for its ability to induce mitogenicity in mouse spleen cells, pyrogenicity in rabbits, and toxic lethality in galactosamine-sensitized mice. Compared with those for enterobacterial lipopolysaccharide, mitogenicity and pyrogenicity were a thousand-fold lower and lethal toxicity was 500-fold lower. We suggest that the phosphorylation pattern and acylation in lipid A are responsible for the low biological activity.

摘要

对来自胃十二指肠病原体幽门螺杆菌的脂多糖进行了检测，以评估其在小鼠脾细胞中诱导有丝分裂原性的能力、在兔体内的致热原性以及在半乳糖胺致敏小鼠中的致死毒性。与肠杆菌脂多糖相比，有丝分裂原性和致热原性低一千倍，致死毒性低五百倍。我们认为脂质A中的磷酸化模式和酰化作用是其低生物活性的原因。