幽门螺杆菌脂多糖的生物活性较低。
Low biological activity of Helicobacter pylori lipopolysaccharide.
作者信息
Muotiala A, Helander I M, Pyhälä L, Kosunen T U, Moran A P
机构信息
Department of Bacteriology, National Public Health Institute, Helsinki, Finland.
出版信息
Infect Immun. 1992 Apr;60(4):1714-6. doi: 10.1128/iai.60.4.1714-1716.1992.
Abstract
Lipopolysaccharide from the gastroduodenal pathogen Helicobacter pylori was tested for its ability to induce mitogenicity in mouse spleen cells, pyrogenicity in rabbits, and toxic lethality in galactosamine-sensitized mice. Compared with those for enterobacterial lipopolysaccharide, mitogenicity and pyrogenicity were a thousand-fold lower and lethal toxicity was 500-fold lower. We suggest that the phosphorylation pattern and acylation in lipid A are responsible for the low biological activity.
摘要
对来自胃十二指肠病原体幽门螺杆菌的脂多糖进行了检测，以评估其在小鼠脾细胞中诱导有丝分裂原性的能力、在兔体内的致热原性以及在半乳糖胺致敏小鼠中的致死毒性。与肠杆菌脂多糖相比，有丝分裂原性和致热原性低一千倍，致死毒性低五百倍。我们认为脂质A中的磷酸化模式和酰化作用是其低生物活性的原因。
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