O'Connor B L, Visco D M, Brandt K D, Myers S L, Kalasinski L A
Department of Anatomy, Indiana University School of Medicine, Indianapolis 46202-5120.
J Bone Joint Surg Am. 1992 Mar;74(3):367-76.
The development of osteoarthrosis in unstable knee joints of dogs after transection of the anterior cruciate ligament is greatly accelerated when the afferent nerve fibers from the ipsilateral hindlimb have been interrupted by dorsal root ganglionectomy before transection. The purpose of the current study was to determine whether partial loss of the afferent fibers from the knee joints of dogs, accomplished by neurectomy of the primary articular nerves before transection of the ligament, also accelerates the development of osteoarthrosis. Osteoarthrosis did not develop in dogs that had had transection of the medial, posterior, and lateral articular nerves to the left knee joint but had an intact anterior cruciate ligament. Osteoarthrosis developed in all dogs that had had transection of the anterior cruciate ligament. However, the osteoarthrotic lesions, as gauged by histological and macroscopic criteria, were more frequent and severe in dogs that had had neurectomy before transection than in those that had intact sensory nerves and an unstable joint (p less than or equal to 0.05). A subchondral fracture occurred in three dogs that had had neurectomy and had an unstable joint but in none of the dogs that had intact sensory nerves and an unstable joint.
在切断前交叉韧带后，若在切断前通过背根神经节切除术中断同侧后肢的传入神经纤维，犬不稳定膝关节骨关节炎的发展会大大加速。本研究的目的是确定在切断韧带前通过切断主要关节神经进行神经切除术，使犬膝关节传入纤维部分丧失，是否也会加速骨关节炎的发展。切断左膝关节的内侧、后外侧关节神经但前交叉韧带完整的犬未发生骨关节炎。所有切断前交叉韧带的犬均发生了骨关节炎。然而，根据组织学和宏观标准判断，切断前进行神经切除术的犬的骨关节炎病变比感觉神经完整且关节不稳定的犬更频繁、更严重（p小于或等于0.05）。三只进行了神经切除术且关节不稳定的犬发生了软骨下骨折，而感觉神经完整且关节不稳定的犬均未发生。
