O'Connor B L, Visco D M, Brandt K D, Albrecht M, O'Connor A B
Department of Anatomy, Indiana University School of Medicine, Indiana University Multipurpose Arthritis and Musculoskeletal Disease Center, Indianapolis.
Arthritis Rheum. 1993 Aug;36(8):1154-63. doi: 10.1002/art.1780360817.
The slow rate at which articular cartilage degrades in dogs after transection of the anterior cruciate ligament (ACLT) has been attributed to capsular thickening and buttressing by osteophytes. We investigated the roles of the peripheral and central nervous systems in protecting knee joints with chronic ACL deficiency from breakdown.
Five groups of dogs were studied; all were killed 72 weeks after left knee surgery. Group A had ACLT, group B had ACLT followed 52 weeks later by ipsilateral L4-S1 dorsal root ganglionectomy (DRG), group C had DRG followed 2 weeks later by ACLT, group D had sham DRG followed 2 weeks later by ACLT, and group E had DRG followed 2 weeks later by sham ACTL.
Group E dogs did not develop knee pathology. All cruciate-deficient knees were lax at the end of the study. The osteoarthritis (OA) that developed in groups A, B, and D was comparable (P > 0.05), and was significantly greater than that in group E (P < 0.05). Group C developed much more severe OA than any of the other groups (P < 0.05).
Ipsilateral sensory input is temporarily important in protecting the unstable joint from rapid breakdown. Over time, the central nervous system apparently acquires the ability to protect the unstable joint without continued ipsilateral sensory input.
犬前交叉韧带切断术（ACLT）后关节软骨降解速度缓慢，这归因于关节囊增厚和骨赘支撑。我们研究了外周和中枢神经系统在保护慢性前交叉韧带缺乏的膝关节免于破坏中的作用。
研究了五组犬；所有犬在左膝手术后72周处死。A组进行了ACLT，B组在ACLT后52周进行同侧L4-S1背根神经节切除术（DRG），C组在DRG后2周进行ACLT，D组在假DRG后2周进行ACLT，E组在DRG后2周进行假ACLT。
E组犬未出现膝关节病变。在研究结束时，所有交叉韧带缺乏的膝关节都松弛。A组、B组和D组出现的骨关节炎（OA）程度相当（P>0.05），且明显高于E组（P<0.05）。C组出现的OA比其他任何组都严重得多（P<0.05）。
同侧感觉输入在保护不稳定关节免于快速破坏方面暂时很重要。随着时间的推移，中枢神经系统显然获得了在没有持续同侧感觉输入的情况下保护不稳定关节的能力。
