Pouli N, Fytas G, Foscolos G B, Kolocouris N, Marakos P, Vamvakides A
Laboratoire de Chimie Pharmaceutique, Université d'Athènes, Grèce.
Ann Pharm Fr. 1995;53(4):163-9.
gamma-(1-Adamantyl)benzenepropanamines and gamma-(1-adamantyl)benzene-beta-propenamines were synthesized and their pharmacological action was studied on mice. Behavioral effects obtained with these compounds and specially the study of convulsions, induced by these derivatives, could show a rise of the gamma-(1-adamantyl)benzenepropanamine's antinicotinic component, which is characteristic of all the adamantanamines. On the contrary gamma-(1-adamantyl)benzene-beta-propenamine's molecular torsion, induced by the double bond, coudl confer to these derivatives agonistic properties on the central nicotinic receptor sites.
