圆叶鹅掌柴的细胞毒性皂苷

Cytotoxic saponins from Schefflera rotundifolia.

作者信息

Braca Alessandra, Autore Giuseppina, De Simone Francesco, Marzocco Stefania, Morelli Ivano, Venturella Fabio, De Tommasi Nunziatina

机构信息

Dipartimento di Chimica Bioorganica e Biofarmacia, Università di Pisa, Pisa, Italy.

出版信息

Planta Med. 2004 Oct;70(10):960-6. doi: 10.1055/s-2004-832623.

DOI:10.1055/s-2004-832623

PMID:15490325

Abstract

Eight new oleanane and lupane saponins (1-8) as well as two new benzyl glycosides (9 and 10) were isolated from the aerial parts of Schefflera rotundifolia (Ten) Frodin (Araliaceae) together with two known benzyl glycosides. Their structures were established using 1D- and 2D-NMR spectroscopy and mass spectrometry. The antiproliferative activity of all compounds was evaluated using three continuous murine and human culture cell lines J774.A1, HEK-293, and WEHI-164. Compounds 7 and 8, having betulinic acid as aglycone, were the most active constituents.

摘要

从圆叶鹅掌柴（五加科）地上部分分离得到8个新的齐墩果烷型和羽扇豆烷型皂苷（1-8）以及2个新的苄基糖苷（9和10），同时还得到2个已知的苄基糖苷。通过一维和二维核磁共振光谱以及质谱确定了它们的结构。使用三种连续的小鼠和人类培养细胞系J774.A1、HEK-293和WEHI-164评估了所有化合物的抗增殖活性。以桦木酸为苷元的化合物7和8是活性最强的成分。