来自粟米草根部的具有抗增殖作用的何帕烷和齐墩果烷糖苷。

Antiproliferative hopane and oleanane glycosides from the roots of Glinus lotoides.

作者信息

Hamed Arafa I, Piacente Sonia, Autore Giuseppina, Marzocco Stefania, Pizza Cosimo, Oleszek Wieslaw

机构信息

Botany Department, Aswan Faculty of Science, South Valley University, Aswan, Egypt.

出版信息

Planta Med. 2005 Jun;71(6):554-60. doi: 10.1055/s-2005-864158.

DOI:10.1055/s-2005-864158

PMID:15971128

Abstract

Three new hopane saponins, lotoidosides A - C (1 - 3), and four new oleanane saponins, lotoidosides D - G (4 - 7), were isolated from the roots of Glinus lotoides L. (Molluginaceae). Their structures were determined by extensive 1D- and 2D-NMR spectroscopy and ESI-MS analysis. The antiproliferative activity of compounds 1 - 7 was evaluated using three continuous murine and human culture cell lines J774.A1, HEK-293, WEHI-164. Compounds 1 and 3 - 7 showed significant cytotoxicity against the three cancer cell lines with IC50 values ranging from 0.018 to 0.62 microM, while compound 2 exerted a weak activity only against the cell line HEK-293.

摘要

从粟米草（粟米草科）的根中分离出了三种新的何帕烷皂苷，即粟米草苷A - C（1 - 3），以及四种新的齐墩果烷皂苷，即粟米草苷D - G（4 - 7）。通过广泛的一维和二维核磁共振光谱以及电喷雾电离质谱分析确定了它们的结构。使用三种连续的小鼠和人类培养细胞系J774.A1、HEK - 293、WEHI - 164评估了化合物1 - 7的抗增殖活性。化合物1和3 - 7对这三种癌细胞系显示出显著的细胞毒性，IC50值范围为0.018至0.62微摩尔，而化合物2仅对细胞系HEK - 293表现出较弱的活性。