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意大利西西里岛采集的野生和栽培物种的植物化学特征、抗氧化及抗增殖活性

Phytochemical Characterization, Antioxidant, and Anti-Proliferative Activities of Wild and Cultivated Species Collected in Sicily (Italy).

作者信息

Scognamiglio Monica, Maresca Viviana, Basile Adriana, Pacifico Severina, Fiorentino Antonio, Bruno Maurizio, Badalamenti Natale, Kapelusz Marta, Marino Pasquale, Capasso Lucia, Bontempo Paola, Bazan Giuseppe

机构信息

Department of Environmental, Biological and Pharmaceutical Sciences and Technologies (DiSTABiF), University of Campania "Luigi Vanvitelli", Via Vivaldi 43, 81100 Caserta, Italy.

Department of Biology, University of Naples "Federico II", 80138 Naples, Italy.

出版信息

Antioxidants (Basel). 2024 Mar 27;13(4):402. doi: 10.3390/antiox13040402.

DOI:10.3390/antiox13040402
PMID:38671850
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11047655/
Abstract

The use of seeds in the culinary field or as aerial parts infusions in the pharmaceutical and cosmetic fields is widely reported. The biological activity of this plant, as demonstrated over the years, is closely related to its phytochemical content. This investigation focused on the comparative study of the same plants of , one totally wild (), while the other two, one with white flowers () and the other with blue flowers (), were subject to cultivation, irrigation, and manual weeding. Using the potential of 1D and 2D-NMR spectroscopy, coupled with MS/MS spectrometric studies, the three methanolic extracts of were investigated. Chemical studies have highlighted the presence of triterpene saponin compounds and various glycosylated flavonoids. Finally, the in vitro antiproliferative and antioxidant activities of the three individual extracts were evaluated. The antiproliferative activity performed on U-937, HL-60, and MCF-7 tumor cell lines highlighted a greater anticancer effect of the and extracts compared to the data obtained using . The antioxidant activity, however, performed to quantify ROS generation is comparable among the extracts used.

摘要

种子在烹饪领域的应用，或作为药用和化妆品领域地上部分的浸剂，已有广泛报道。多年来所证实的这种植物的生物活性与其植物化学成分密切相关。本研究聚焦于对[植物名称]相同植株的比较研究，其中一株完全野生（[野生植株名称]），另外两株，一株开白花（[白花植株名称]），另一株开蓝花（[蓝花植株名称]），进行了栽培、灌溉和人工除草。利用一维和二维核磁共振光谱的潜力，结合串联质谱研究，对[植物名称]的三种甲醇提取物进行了研究。化学研究突出了三萜皂苷化合物和各种糖基化黄酮类化合物的存在。最后，评估了三种单独提取物的体外抗增殖和抗氧化活性。在U - 937、HL - 60和MCF - 7肿瘤细胞系上进行的抗增殖活性表明，与使用[某种提取物]所获得的数据相比，[另外两种提取物名称]提取物具有更强的抗癌作用。然而，为量化活性氧生成而进行的抗氧化活性在所用提取物之间具有可比性。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0492/11047655/2d8c43f89aae/antioxidants-13-00402-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0492/11047655/5ddf967cd415/antioxidants-13-00402-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0492/11047655/9323333854ec/antioxidants-13-00402-g009.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0492/11047655/5a4597ed632b/antioxidants-13-00402-g012.jpg

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