来自德纳姆美杨桐的具有抗增殖作用的齐墩果烷皂苷。

Antiproliferative oleanane saponins from Meryta denhamii.

作者信息

Cioffi Giuseppina, Dal Piaz Fabrizio, Vassallo Antonio, Venturella Fabio, De Caprariis Paolo, De Simone Francesco, De Tommasi Nunziatina

机构信息

Dipartimento di Scienze Farmaceutiche, Universitaàdi Salerno, Via Ponte Don Melillo, 84084 Fisciano (SA), Italy.

出版信息

J Nat Prod. 2008 Jun;71(6):1000-4. doi: 10.1021/np8000464. Epub 2008 Apr 29.

DOI:10.1021/np8000464

PMID:18442289

Abstract

Eight new oleanane saponins (1- 8) together with four know saponins (9-12) were isolated from the aerial parts of Meryta denhamii. Their structures were elucidated by 1D and 2D NMR experiments including 1D TOCSY, DQF-COSY, ROESY, HSQC, and HMBC spectroscopy, as well as ESIMS analysis. The antiproliferative activity of all compounds was evaluated using three murine and human cancer cell lines: J774.A1, HEK-293, and WEHI-164.

摘要

从丹汉姆刺葵的地上部分分离出8种新的齐墩果烷皂苷（1-8）以及4种已知皂苷（9-12）。通过一维和二维核磁共振实验（包括一维全相关谱、双量子滤波相关谱、旋转框架核Overhauser效应谱、异核单量子相干谱和异核多键相关谱）以及电喷雾离子化质谱分析确定了它们的结构。使用三种鼠类和人类癌细胞系：J774.A1、人胚肾细胞-293和WEHI-164评估了所有化合物的抗增殖活性。