日本儿童及其父母中牙周病致病菌的分布情况。
The distribution of periodontopathic bacteria among Japanese children and their parents.
作者信息
Umeda Makoto, Miwa Zenzo, Takeuchi Yasuo, Ishizuka Motoko, Huang Yi, Noguchi Kazuyuki, Tanaka Mitsuro, Takagi Yuzo, Ishikawa Isao
机构信息
Section of Periodontology, Department of Hard Tissue Engineering, Tokyo Medical and Dental University, Japan.
出版信息
J Periodontal Res. 2004 Dec;39(6):398-404. doi: 10.1111/j.1600-0765.2004.00754.x.
OBJECTIVE AND BACKGROUND
It is not well known how periodontopathic bacteria colonize in the oral cavity during childhood. The purpose of this study was to investigate the distribution of periodontopathic bacteria in oral cavities of children and their parents and the relationship between the bacterial findings and clinical parameters.
METHODS
Fifty-six children (mean age: 8.3 +/- 3.5, range: 1-15 years), including 15 with deciduous dentition, 26 with mixed dentition and 15 with permanent dentition, and their parents participated in this study. Whole saliva and dental plaque of the children and whole saliva of their parents were collected for detection of seven species of periodontopathic bacteria (Actinobacillus actinomycetemcomitans, Tannerella forsythensis (Bacteroides forsythus), Campylobacter rectus, Porphyromonas gingivalis, Prevotella intermedia, Prevotella nigrescens and Treponema denticola) using the polymerase chain reaction method. Clinical parameters including simplified Oral Hygiene Index and Papillary-Marginal-Attachment Index were recorded for the children and their accompanied parents.
RESULTS
The detection frequencies of T. forsythensis, C. rectus, P. nigrescens, T. denticola, A. actinomycetemcomitans and P. gingivalis in the oral cavities of children were 42.9%, 94.6%, 42.9%, 48.2%, 1.8% and 8.9%, respectively. T. forsythensis, P. gingivalis and T. denticola were detected more frequently in the saliva of parents (54.8%, 54.8%, 88.1%, respectively) than in the saliva of children (25.5%, 7.3%, 41.8%, respectively). Different detection frequencies of P. nigrescens were found among the oral cavities of children with deciduous, mixed and permanent dentitions. In mixed dentition, females harbored T. forsythensis more frequently than males did. Children who harbored T. forsythensis, P. intermedia, P. nigrescens and T. denticola showed high scores for oral debris measurement by simplified Oral Hygiene Index. T. forsythensis, P. intermedia and P. nigrescens were detected more frequently in children whose parents were positive for these pathogens than in children whose parents were negative.
CONCLUSIONS
High plaque retention seems to promote the colonization of periodontal pathogens in the oral cavities of children. T. forsythensis, P. intermedia and P. nigrescens were detected more frequently in the oral cavities of children whose parents already harbored these bacteria. Familial transmission of these bacteria is suggested.
目的与背景
儿童时期牙周病原菌如何在口腔内定植尚不清楚。本研究旨在调查儿童及其父母口腔中牙周病原菌的分布情况，以及细菌检测结果与临床参数之间的关系。
方法
56名儿童（平均年龄：8.3±3.5岁，范围：1 - 15岁），包括15名乳牙列儿童、26名混合牙列儿童和15名恒牙列儿童及其父母参与了本研究。收集儿童的全唾液和牙菌斑以及其父母的全唾液，采用聚合酶链反应法检测7种牙周病原菌（伴放线放线杆菌、福赛坦氏菌（原福赛拟杆菌）、直肠弯曲菌、牙龈卟啉单胞菌、中间普氏菌、变黑普氏菌和齿垢密螺旋体）。记录儿童及其陪同父母的临床参数，包括简化口腔卫生指数和乳头 - 边缘 - 附着指数。
结果
儿童口腔中福赛坦氏菌、直肠弯曲菌、变黑普氏菌、齿垢密螺旋体、伴放线放线杆菌和牙龈卟啉单胞菌的检出频率分别为42.9%、94.6%、42.9%、48.2%、1.8%和8.9%。福赛坦氏菌、牙龈卟啉单胞菌和齿垢密螺旋体在父母唾液中的检出频率（分别为54.8%、54.8%、88.1%）高于儿童唾液中的检出频率（分别为25.5%、7.3%、41.8%）。在乳牙列、混合牙列和恒牙列儿童的口腔中，变黑普氏菌的检出频率不同。在混合牙列中，女性携带福赛坦氏菌的频率高于男性。携带福赛坦氏菌、中间普氏菌、变黑普氏菌和齿垢密螺旋体的儿童简化口腔卫生指数的口腔碎屑测量得分较高。父母感染这些病原菌呈阳性的儿童中，福赛坦氏菌、中间普氏菌和变黑普氏菌的检出频率高于父母感染呈阴性的儿童。
结论
高菌斑滞留似乎促进了牙周病原菌在儿童口腔中的定植。在父母已携带这些细菌的儿童口腔中，福赛坦氏菌、中间普氏菌和变黑普氏菌的检出频率更高。提示这些细菌存在家族传播。
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