单色准分子激光辐射（308纳米）治疗早期蕈样肉芽肿的疗效
Efficacy of monochromatic excimer laser radiation (308 nm) in the treatment of early stage mycosis fungoides.
作者信息
Nisticò S, Costanzo A, Saraceno R, Chimenti S
机构信息
Department of Dermatology, University of Rome Policlinico Tor Vergata, Viale Oxford 81, 00133 Rome, Italy.
出版信息
Br J Dermatol. 2004 Oct;151(4):877-9. doi: 10.1111/j.1365-2133.2004.06178.x.
BACKGROUND
Various reports have recently shown the efficacy of narrowband ultraviolet (UV) B phototherapy at 311 nm in the treatment of early stage mycosis fungoides (MF).
OBJECTIVES
To examine the effectiveness and tolerability of monochromatic excimer light (MEL) at 308 nm as a first treatment for early stage MF (stage IA).
METHODS
Ten lesions from five patients with a clinical and histological diagnosis of MF were treated with repeated applications of MEL until complete remission was achieved or up to a maximum of 10 applications, with a cumulative dose of 308 nm UVB of between 6 and 12 J cm(-2). All patients were observed every 2 weeks for 2 months, with a 1-year follow-up. Results At present, all patients are in complete remission, with no side-effects.
CONCLUSIONS
Based on these results, MEL can be considered a useful tool in the treatment of early stage MF.
背景
最近的各种报告显示，311纳米的窄带紫外线B光疗在治疗早期蕈样肉芽肿（MF）方面具有疗效。
目的
研究308纳米的单色准分子光（MEL）作为早期MF（IA期）的首次治疗方法的有效性和耐受性。
方法
对5例临床和组织学诊断为MF的患者的10个皮损进行反复MEL照射治疗，直至完全缓解或最多照射10次，308纳米紫外线B的累积剂量为6至12焦每平方厘米。每2周观察所有患者，持续2个月，并进行1年随访。结果目前，所有患者均完全缓解，且无副作用。
结论
基于这些结果，MEL可被视为治疗早期MF的一种有用工具。
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