基于壳聚糖的药物递送微纳米颗粒的最新进展

Recent advances on chitosan-based micro- and nanoparticles in drug delivery.

作者信息

Agnihotri Sunil A, Mallikarjuna Nadagouda N, Aminabhavi Tejraj M

机构信息

Drug Delivery Division, Center of Excellence in Polymer Science, Karnatak University, Dharwad 580 003, India.

出版信息

J Control Release. 2004 Nov 5;100(1):5-28. doi: 10.1016/j.jconrel.2004.08.010.

DOI:10.1016/j.jconrel.2004.08.010

PMID:15491807

Abstract

Considerable research efforts have been directed towards developing safe and efficient chitosan-based particulate drug delivery systems. The present review outlines the major new findings on the pharmaceutical applications of chitosan-based micro/nanoparticulate drug delivery systems published over the past decade. Methods of their preparation, drug loading, release characteristics, and applications are covered. Chemically modified chitosan or its derivatives used in drug delivery research are discussed critically to evaluate the usefulness of these systems in delivering the bioactive molecules. From a literature survey, it is realized that research activities on chitosan micro/nanoparticulate systems containing various drugs for different therapeutic applications have increased at the rapid rate. Hence, the present review is timely.

摘要

大量的研究工作致力于开发安全、高效的基于壳聚糖的微粒药物递送系统。本综述概述了过去十年发表的关于基于壳聚糖的微/纳米微粒药物递送系统在制药应用方面的主要新发现。涵盖了它们的制备方法、载药、释放特性及应用。对用于药物递送研究的化学修饰壳聚糖或其衍生物进行了批判性讨论，以评估这些系统在递送生物活性分子方面的实用性。通过文献调查发现，针对不同治疗应用、含有各种药物的壳聚糖微/纳米微粒系统的研究活动迅速增加。因此，本综述很及时。