中国南方输血传播病毒的母婴垂直传播

Mother-to-infant vertical transmission of transfusion transmitted virus in South China.

作者信息

Xin Xiao, Xiaoguang Zhou, Ninghu Zhu, Youtong Luo, Liumei Xu, Boping Zhou

机构信息

Perinatal Medicine Center, First Affiliated Hospital of Jinan University, Guangzhou, P.R. China.

出版信息

J Perinat Med. 2004;32(5):404-6. doi: 10.1515/JPM.2004.136.

DOI:10.1515/JPM.2004.136

PMID:15493715

Abstract

A nested PCR was used to detect TTV DNA in serum from 490 mother-infant pairs to determine the rate of vertical transmission of TTV in Guangzhou City, P.R. China. TTV DNA was positive in 87 mothers and 12 of their babies, giving a prevalence of 17.8% in pregnant women and a mother-to-child transmission rate of 13.8%. In eight mother-infant pairs, TTV DNA nucleotide sequences from the mothers and their corresponding infants were identical. The homology of Guangzhou TTV and Japanese TTV ranged from 85.3%-98.2% at nucleotide level. TTV infection is common in pregnant women in South China and vertical transmission can occur. Guangzhou's and Japanese TTV isolates belong to the same genotype.

摘要

采用巢式聚合酶链反应（nested PCR）检测490对母婴血清中的TTV DNA，以确定中国广州市TTV的垂直传播率。87名母亲及其12名婴儿的TTV DNA呈阳性，孕妇患病率为17.8%，母婴传播率为13.8%。在8对母婴中，母亲及其相应婴儿的TTV DNA核苷酸序列相同。广州TTV与日本TTV在核苷酸水平上的同源性为85.3%-98.2%。TTV感染在华南地区孕妇中很常见，且可发生垂直传播。广州和日本的TTV分离株属于同一基因型。