Tyschik Elena A, Shcherbakova Sophia M, Ibragimov Ruslan R, Rebrikov Denis V
Kulakov Research Center for Obstetrics, Gynecology and Perinatology, 117997, Oparina 4, Moscow, Russia.
Pirogov Russian National Research Medical University, 117997, Ostrovityanova 1, Moscow, Russia.
Virol J. 2017 May 8;14(1):92. doi: 10.1186/s12985-017-0762-0.
TTV has been detected in almost every human tissue type or body fluid reaching near 100% prevalence. Several studies report mother-to-child postnatal transmission of TTV in infancy but the risk of transplacental transmission of TTV is still unclear.
The blood and plasma collected postpartum from 100 mother-child pairs were analyzed using TTV-specific qPCR. Samples were collected from the peripheral vein of the mother and the umbilical cord.
Eighty four percent of pregnant women were TTV positive (median titers: 8 × 10 copies/mL; range: 10 - 3 × 10). The TTV load in plasma was approximately 100 times lower than in whole blood. TTV was not detected in any of cord blood samples.
Our data demonstrate the lack of transplacental transmission of TTV (or effective prenatal inhibition of viral proliferation). The presence of the virus in infants may be associated with mother-to-child transmission through breast feeding or other routes of transmission.
在几乎每一种人体组织类型或体液中都检测到了TTV，其流行率接近100%。多项研究报告了TTV在婴儿期的母婴产后传播情况，但TTV经胎盘传播的风险仍不明确。
采用TTV特异性定量聚合酶链反应（qPCR）分析100对母婴产后采集的血液和血浆。样本取自母亲的外周静脉和脐带。
84%的孕妇TTV呈阳性（中位数滴度：8×10拷贝/毫升；范围：10 - 3×10）。血浆中的TTV载量比全血中低约100倍。在任何脐带血样本中均未检测到TTV。
我们的数据表明不存在TTV经胎盘传播（或有效的产前病毒增殖抑制）。婴儿体内病毒的存在可能与通过母乳喂养或其他传播途径的母婴传播有关。
