小RNA的新应用：刺激核糖体移码
Novel application of sRNA: stimulation of ribosomal frameshifting.
作者信息
Olsthoorn R C L, Laurs M, Sohet F, Hilbers C W, Heus H A, Pleij C W A
机构信息
Leiden Institute of Chemistry, Section Genexpress, Gorlaeus Laboratories, Leiden University, Einsteinweg 55, P.O. Box 9502, 2300RA Leiden, The Netherlands.
出版信息
RNA. 2004 Nov;10(11):1702-3. doi: 10.1261/rna.7139704.
Abstract
Small RNAs play an important role in regulation of gene expression in eukaryotic and eubacterial cells by modulating gene expression both at the level of transcription and translation. Here, we show that short complementary RNAs can also affect gene expression by stimulating ribosomal frameshifting in vitro. This finding has important implications for understanding the process of ribosomal frameshifting and for the potential application of small RNAs in the treatment of diseases that are due to frameshift mutations.
摘要
小RNA通过在转录和翻译水平上调节基因表达，在真核细胞和原核细胞的基因表达调控中发挥重要作用。在此，我们表明短互补RNA也可通过在体外刺激核糖体移码来影响基因表达。这一发现对于理解核糖体移码过程以及小RNA在治疗由移码突变引起的疾病中的潜在应用具有重要意义。
相似文献
1
Novel application of sRNA: stimulation of ribosomal frameshifting.
RNA. 2004 Nov;10(11):1702-3. doi: 10.1261/rna.7139704.
2
A sequence required for -1 ribosomal frameshifting located four kilobases downstream of the frameshift site.
J Mol Biol. 2001 Jul 27;310(5):987-99. doi: 10.1006/jmbi.2001.4801.
3
Analysis of the roles of tRNA structure, ribosomal protein L9, and the bacteriophage T4 gene 60 bypassing signals during ribosome slippage on mRNA.
J Mol Biol. 2001 Jun 22;309(5):1029-48. doi: 10.1006/jmbi.2001.4717.
4
Asc1, homolog of human RACK1, prevents frameshifting in yeast by ribosomes stalled at CGA codon repeats.
RNA. 2015 May;21(5):935-45. doi: 10.1261/rna.049080.114. Epub 2015 Mar 19.
5
mRNA-Mediated Duplexes Play Dual Roles in the Regulation of Bidirectional Ribosomal Frameshifting.
Int J Mol Sci. 2018 Dec 4;19(12):3867. doi: 10.3390/ijms19123867.
6
A -1 ribosomal frameshift element that requires base pairing across four kilobases suggests a mechanism of regulating ribosome and replicase traffic on a viral RNA.
Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11133-8. doi: 10.1073/pnas.162223099. Epub 2002 Jul 30.
7
Polyamine sensing during antizyme mRNA programmed frameshifting.
Biochem Biophys Res Commun. 2005 Dec 23;338(3):1478-89. doi: 10.1016/j.bbrc.2005.10.115. Epub 2005 Oct 27.
8
Correlation between mechanical strength of messenger RNA pseudoknots and ribosomal frameshifting.
Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):5830-5. doi: 10.1073/pnas.0608668104. Epub 2007 Mar 27.
9
Multi-protein bridging factor 1(Mbf1), Rps3 and Asc1 prevent stalled ribosomes from frameshifting.
Elife. 2018 Nov 22;7:e39637. doi: 10.7554/eLife.39637.
10
E. coli ribosomes re-phase on retroviral frameshift signals at rates ranging from 2 to 50 percent.
New Biol. 1989 Nov;1(2):159-69.
引用本文的文献
1
Programmable modulation of ribosomal frameshifting by mRNA targeting CRISPR-Cas12a system.
iScience. 2023 Nov 19;26(12):108492. doi: 10.1016/j.isci.2023.108492. eCollection 2023 Dec 15.
2
Thinking Outside the Frame: Impacting Genomes Capacity by Programmed Ribosomal Frameshifting.
Front Mol Biosci. 2022 Feb 14;9:842261. doi: 10.3389/fmolb.2022.842261. eCollection 2022.
3
From Recoding to Peptides for MHC Class I Immune Display: Enriching Viral Expression, Virus Vulnerability and Virus Evasion.
Viruses. 2021 Jun 27;13(7):1251. doi: 10.3390/v13071251.
4
Regulators of Viral Frameshifting: More Than RNA Influences Translation Events.
Annu Rev Virol. 2020 Sep 29;7(1):219-238. doi: 10.1146/annurev-virology-012120-101548. Epub 2020 Jun 29.
5
Translational recoding signals: Expanding the synthetic biology toolbox.
J Biol Chem. 2019 May 10;294(19):7537-7545. doi: 10.1074/jbc.REV119.006348. Epub 2019 Apr 1.
6
Translation Elongation and Recoding in Eukaryotes.
Cold Spring Harb Perspect Biol. 2018 Aug 1;10(8):a032649. doi: 10.1101/cshperspect.a032649.
7
Stimulation of reverse transcriptase generated cDNAs with specific indels by template RNA structure: retrotransposon, dNTP balance, RT-reagent usage.
Nucleic Acids Res. 2017 Sep 29;45(17):10143-10155. doi: 10.1093/nar/gkx689.
8
Mechanical unfolding kinetics of the SRV-1 gag-pro mRNA pseudoknot: possible implications for -1 ribosomal frameshifting stimulation.
Sci Rep. 2016 Dec 21;6:39549. doi: 10.1038/srep39549.
9
Ribosomal frameshifting and transcriptional slippage: From genetic steganography and cryptography to adventitious use.
Nucleic Acids Res. 2016 Sep 6;44(15):7007-78. doi: 10.1093/nar/gkw530. Epub 2016 Jul 19.
10
Reprogramming the genetic code: The emerging role of ribosomal frameshifting in regulating cellular gene expression.
Bioessays. 2016 Jan;38(1):21-6. doi: 10.1002/bies.201500131. Epub 2015 Dec 12.
本文引用的文献
1
Efficient stimulation of site-specific ribosome frameshifting by antisense oligonucleotides.
RNA. 2004 Oct;10(10):1653-61. doi: 10.1261/rna.7810204.
2
Identification of a new antizyme mRNA +1 frameshifting stimulatory pseudoknot in a subset of diverse invertebrates and its apparent absence in intermediate species.
J Mol Biol. 2004 Jun 4;339(3):495-504. doi: 10.1016/j.jmb.2004.03.082.
3
Structure and function of the stimulatory RNAs involved in programmed eukaryotic-1 ribosomal frameshifting.
Cold Spring Harb Symp Quant Biol. 2001;66:233-48. doi: 10.1101/sqb.2001.66.233.
4
An "integrated model" of programmed ribosomal frameshifting.
Trends Biochem Sci. 2002 Sep;27(9):448-54. doi: 10.1016/s0968-0004(02)02149-7.
5
Structure, stability and function of RNA pseudoknots involved in stimulating ribosomal frameshifting.
J Mol Biol. 2000 Apr 28;298(2):167-85. doi: 10.1006/jmbi.2000.3668.
6
Identification and analysis of the pseudoknot-containing gag-pro ribosomal frameshift signal of simian retrovirus-1.
Nucleic Acids Res. 1994 Jun 25;22(12):2304-10. doi: 10.1093/nar/22.12.2304.
7
Mutational analysis of the "slippery-sequence" component of a coronavirus ribosomal frameshifting signal.
J Mol Biol. 1992 Sep 20;227(2):463-79. doi: 10.1016/0022-2836(92)90901-u.
Zotero 插件