Shields Jerry A, Shields Carol L, Materin Miguel A, Marr Brian P, Demirci Hakan, Mashayekhi Arman
Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.
Ophthalmic Surg Lasers Imaging. 2004 Sep-Oct;35(5):383-94.
To review trends in the management of circumscribed choroidal hemangioma (CCH) and to propose treatment guidelines based on review of recent literature and the authors' personal experience with more than 250
The English-language literature on the management of CCH was reviewed, with emphasis on changing concepts in recent years.
Xenon arc and argon laser photocoagulation and thermotherapy have been used to treat CCH with localized retinal detachment, but there has recently been enthusiasm for photodynamic therapy (PDT) using fluorescein angiography and optical coherence tomography to monitor subretinal fluid and cystoid retinal edema before and after treatment. Tumors with extensive retinal detachment have been managed by surgical attempts at retinal reattachment followed by photocoagulation or cryotherapy, and more recently by radiotherapy. Management currently includes observation, argon laser photocoagulation, transpupillary thermotherapy, PDT, and radiotherapy. Enucleation may be necessary in rare cases. The goal of treatment should be to induce resolution of existing retinal detachment and to improve or stabilize visual loss.
There is increasing use of PDT for CCH with localized retinal detachment and radiotherapy for CCH with more extensive detachment. Although follow-up is short, current methods may achieve better tumor control and better visual outcome. However, caution is advised because long-term follow-up is still not available.
回顾局限性脉络膜血管瘤(CCH)的治疗趋势,并根据近期文献综述及作者超过250例的个人经验提出治疗指南。
回顾英文文献中关于CCH治疗的内容,重点关注近年来观念的变化。
氙弧光凝、氩激光光凝和热疗曾用于治疗伴有局限性视网膜脱离的CCH,但近年来人们热衷于采用光动力疗法(PDT),利用荧光素血管造影和光学相干断层扫描在治疗前后监测视网膜下液和黄斑囊样水肿。对于伴有广泛视网膜脱离的肿瘤,曾尝试通过手术使视网膜复位,随后进行光凝或冷冻治疗,近来则采用放射治疗。目前的治疗方法包括观察、氩激光光凝、经瞳孔温热疗法、PDT和放射治疗。在罕见情况下可能需要眼球摘除术。治疗的目标应是促使现有视网膜脱离消退,并改善或稳定视力丧失情况。
对于伴有局限性视网膜脱离的CCH,PDT的应用越来越多;对于伴有更广泛脱离的CCH,放射治疗的应用越来越多。尽管随访时间较短,但目前的方法可能实现更好的肿瘤控制和更好的视力预后。然而,由于尚无长期随访结果,建议谨慎对待。