Goldacre M J, Wotton C J, Seagroatt V, Yeates D
Unit of Health-Care Epidemiology, Department of Health, University of Oxford, Oxford, UK.
Arch Dis Child. 2004 Nov;89(11):1014-7. doi: 10.1136/adc.2003.046219.
To determine the risk of cancers and selected immune related diseases in people with Down's syndrome, relative to risk in other people.
Cohort analysis of a linked dataset of abstracts of hospital and death records; results expressed as the ratios of rates of disease in people with and without Down's syndrome.
The former Oxford health region, England, 1963-1999.
Cohort of 1453 people with Down's syndrome and cohort of 460,000 people with other conditions for comparison.
As expected, the rate ratio for leukaemia was substantially elevated in people with Down's syndrome: it was 19-fold higher (95% confidence intervals 10.4 to 31.5) than the rate in the comparison cohort. For other cancers combined, excluding leukaemia, the rate ratio was not significantly elevated (1.2; 0.6 to 2.2). The risk of testicular cancer was increased (12.0; 2.5 to 35.6), although this was based on only three cases in the cohort of subjects with Down's syndrome. Significantly elevated risks were found for coeliac disease (4.7; 1.3 to 12.2), acquired hypothyroidism (9.4; 3.4, 20.5), other thyroid disorders, and type 1 diabetes mellitus (2.8; 1.0 to 6.1). A decreased risk was found for asthma (0.4; 0.2 to 0.6).
Our data add to the body of information on the risks of co-morbidity in people with Down's syndrome. The finding on asthma needs to be confirmed or refuted by other studies.
确定唐氏综合征患者患癌症及某些免疫相关疾病的风险，并与其他人的风险作比较。
对医院摘要和死亡记录的关联数据集进行队列分析；结果以唐氏综合征患者与非唐氏综合征患者的疾病发病率之比表示。
英国前牛津健康地区，1963 - 1999年。
1453名唐氏综合征患者队列以及460,000名患有其他疾病的对照队列。
正如预期，唐氏综合征患者白血病的发病率比显著升高：比对照队列高19倍（95%置信区间10.4至31.5）。对于其他合并癌症（不包括白血病），发病率比未显著升高（1.2；0.6至2.2）。睾丸癌风险增加（12.0；2.5至35.6），不过这仅基于唐氏综合征患者队列中的3例病例。发现乳糜泻（4.7；1.3至12.2）、获得性甲状腺功能减退（9.4；3.4至20.5）、其他甲状腺疾病以及1型糖尿病（2.8；1.0至6.1）的风险显著升高。哮喘风险降低（0.4；0.2至0.6）。
我们的数据增加了关于唐氏综合征患者共病风险的信息。关于哮喘的发现需要其他研究予以证实或反驳。
