睾丸精原细胞瘤与唐氏综合征。
Testicular seminoma and Down's syndrome.
作者信息
Roberge D, Souhami L, Laplante M
机构信息
Department of Oncology (Division of Radiation Oncology) McGill University, Montreal, Quebec, Canada.
出版信息
Can J Urol. 2001 Feb;8(1):1203-6.
OBJECTIVE
To review cases of testicular seminoma in Down's syndrome (DS) patients.
METHODS
The case of a patient diagnosed and treated at our institution is reported. The literature is reviewed for previous cases, with attention paid to age, stage, treatment and outcome.
RESULTS
Nineteen cases were found. The mean age at diagnosis is 32. Seventy three percent are Stage I. At 47, our patient is the oldest reported case. A body of evidence exists for an association between DS and testicular seminoma. An increased rate of cryptorchidism, increased gonadotropin levels and genetic instability are possible pathways.
CONCLUSION
The age distribution of seminoma in DS is skewed by the decreased life expectancy of patients with DS. More cases should be seen as this life expectancy increases. The stage at presentation in DS patients is comparable to that seen in the general population. Standard therapy has been successfully delivered in these patients.
目的
回顾唐氏综合征（DS）患者睾丸精原细胞瘤的病例。
方法
报告在我们机构诊断和治疗的一名患者的病例。回顾以往病例的文献，关注年龄、分期、治疗及结果。
结果
共发现19例。诊断时的平均年龄为32岁。73%为Ⅰ期。我们的患者47岁，是报告的年龄最大的病例。有证据表明DS与睾丸精原细胞瘤之间存在关联。隐睾发生率增加、促性腺激素水平升高和基因不稳定可能是相关途径。
结论
DS患者中精原细胞瘤的年龄分布因DS患者预期寿命降低而有所偏差。随着预期寿命增加，将会发现更多病例。DS患者就诊时的分期与普通人群相似。这些患者已成功接受标准治疗。
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