Senn Stephen
Department of Statistics, University of Glasgow, Glasgow G12 8QQ.
BMJ. 2004 Oct 23;329(7472):966-8. doi: 10.1136/bmj.329.7472.966.
Most drug trials assume that patients respond consistently to treatment, but the assumption is rarely tested. If patients vary randomly in their response to a drug rather than some patients never responding, searches for a genetic basis for non-response are futile
大多数药物试验都假定患者对治疗的反应是一致的，但这一假定很少得到验证。如果患者对药物的反应是随机变化的，而不是一些患者根本没有反应，那么寻找无反应的基因基础的研究就是徒劳的。
