Soni P Sarita, Nguyen Tracy T, Bonanno Joseph A
Borish Center for Ophthalmic Research, School of Optometry, Indiana University, Bloomington, IN 47405, USA.
Eye Contact Lens. 2004 Oct;30(4):254-62; discussion 263-4. doi: 10.1097/01.icl.0000140637.58027.9b.
To determine the refractive and corneal topographic recovery after the use of reverse-geometry contact lenses for overnight orthokeratology.
Both eyes of 15 subjects were fitted with reverse-geometry contact lenses that were worn by the subjects for 1 month. Uncorrected visual acuity, refractive correction (sphere and spherical equivalent), corneal curvature, and corneal thickness were measured during this time and for 2 weeks after discontinuation of lens wear.
Ten subjects completed the investigation. Uncorrected visual acuity, refractive correction, and corneal curvature had changed significantly (P = 0.01) after 1 month of lens wear. By the end of 1 month, central corneal thickness was significantly thinner than the baseline value (P = 0.01), but it recovered fully after one night of no lens wear. Recovery of corneal curvature was complete 1 week after lens wear was discontinued. Refractive correction and binocular uncorrected visual acuity recovered fully after 2 weeks. Monocular uncorrected visual acuity remained significantly (P = 0.01) different from baseline acuity 2 weeks after lens discontinuation.
Full effect of overnight orthokeratology in low myopes is achieved within 1 week of initiating use of reverse-geometry lenses. Recovery after short-term use of reverse-geometry lenses is rapid for corneal thickness and corneal curvature. Refractive correction and binocular uncorrected visual acuity recovered fully after 2 weeks. Monocular uncorrected visual acuity was the slowest to recover and had not achieved full recovery after 2 weeks.
确定使用反转几何设计的角膜塑形镜进行夜间角膜塑形术后的屈光和角膜地形图恢复情况。
15名受试者的双眼均佩戴反转几何设计的角膜塑形镜，佩戴时间为1个月。在此期间以及停止佩戴镜片后2周内，测量未矫正视力、屈光矫正（球镜和球镜等效度）、角膜曲率和角膜厚度。
10名受试者完成了研究。佩戴镜片1个月后，未矫正视力、屈光矫正和角膜曲率发生了显著变化（P = 0.01）。到1个月末，中央角膜厚度明显薄于基线值（P = 0.01），但在停止佩戴镜片一晚后完全恢复。停止佩戴镜片1周后，角膜曲率完全恢复。屈光矫正和双眼未矫正视力在2周后完全恢复。停止佩戴镜片2周后，单眼未矫正视力仍与基线视力有显著差异（P = 0.01）。
在开始使用反转几何设计镜片的1周内，低度数近视患者夜间角膜塑形术的全部效果得以实现。短期使用反转几何设计镜片后，角膜厚度和角膜曲率的恢复迅速。屈光矫正和双眼未矫正视力在2周后完全恢复。单眼未矫正视力恢复最慢，2周后未完全恢复。
