Deubzer Hedwig E, Obaro Stephen K, Newman Vanessa O, Adegbola Richard A, Greenwood Brian M, Henderson Don C
Imperial College, Faculty of Medicine, Department of Immunology, Chelsea and Westminster Hospital, London, United Kingdom.
J Infect Dis. 2004 Nov 15;190(10):1758-61. doi: 10.1086/424597. Epub 2004 Oct 7.
Prevention of nasopharyngeal colonization may reduce the burden of pneumococcal infection during infancy. Colostrum obtained from Gambian mothers who had been vaccinated with either Pneumovax II or Mengivax A&C (n=8 per group) during pregnancy was examined for inhibition of adherence of Streptococcus pneumoniae serotypes 6B and 14 to pharyngeal epithelial cells in vitro. Pneumococcal adherence was significantly reduced in the presence of breast milk (P< or =.0001 for S. pneumoniae serotype 14; P=.036 for serotype 6B), independent of the concentration of secretory IgA antibodies. Maternal vaccination with polyvalent pneumococcal polysaccharide vaccine boosts the capacity of colostrum to inhibit adherence of pneumococci to pharyngeal epithelial cells. In breast-feeding populations, maternal vaccination might prevent pneumococcal disease in young infants.
预防鼻咽部定植可能会减轻婴儿期肺炎球菌感染的负担。检测了从孕期接种过肺炎球菌多糖疫苗23价（Pneumovax II）或A&C群脑膜炎球菌多糖疫苗（Mengivax A&C）的冈比亚母亲（每组8人）获得的初乳对肺炎链球菌6B型和14型体外黏附于咽部上皮细胞的抑制作用。在母乳存在的情况下，肺炎球菌的黏附显著减少（肺炎链球菌14型P≤0.0001；6B型P = 0.036），与分泌型IgA抗体的浓度无关。母亲接种多价肺炎球菌多糖疫苗可增强初乳抑制肺炎球菌黏附咽部上皮细胞的能力。在母乳喂养人群中，母亲接种疫苗可能预防幼儿的肺炎球菌疾病。
