Santos Jussamara B, de Jesus Amélia Ribeiro, Machado Paulo R, Magalhães Andréa, Salgado Kátia, Carvalho Edgar M, Almeida Roque P
Servico de Imunologia, Hospital Universitario Professor Edgard Santos, Universidade Federal da Bahia, Salvador, Bahia, Brazil.
J Infect Dis. 2004 Nov 15;190(10):1793-6. doi: 10.1086/424848. Epub 2004 Oct 18.
Cutaneous leishmaniasis (CL) requires 2-6 months to heal. In an effort to reduce this healing time, we studied topically applied granulocyte-macrophage colony-stimulating factor (GM-CSF) as an adjunct to antimonial therapy. Ten patients received antimony plus topical GM-CSF, and 10 patients received antimony plus placebo (saline). GM-CSF was diluted for topical use and was applied 3 times weekly for 3 weeks (1-2 microg/cm2/lesion). The mean +/- SD healing time was 43 +/- 14 days in the GM-CSF group and was 104+/-79 days in the placebo group (P=.043). Ten (100%) of 10 patients in the GM-CSF group healed within 60 days, compared with 5 (50%) of 10 patients in the placebo group. Two of the patients in the placebo group required retreatment with antimony. In conclusion, topically applied GM-CSF is effective in the management of CL.
皮肤利什曼病（CL）需要2至6个月才能愈合。为了缩短愈合时间，我们研究了局部应用粒细胞巨噬细胞集落刺激因子（GM-CSF）作为锑剂治疗的辅助手段。10名患者接受了锑剂加局部GM-CSF治疗，10名患者接受了锑剂加安慰剂（生理盐水）治疗。GM-CSF经稀释后用于局部，每周应用3次，共3周（1-2微克/平方厘米/皮损）。GM-CSF组的平均愈合时间为43±14天，安慰剂组为104±79天（P = 0.043）。GM-CSF组10名患者中有10名（100%）在60天内愈合，而安慰剂组10名患者中只有5名（50%）。安慰剂组有2名患者需要再次接受锑剂治疗。总之，局部应用GM-CSF对CL的治疗有效。
