Suprien Carvel, Guimarães Luiz H, de Carvalho Lucas P, Machado Paulo R L
Postgraduate Program in Health Sciences, Faculty of Medicine, Federal University of Bahia, Salvador 40026-010, Bahia, Brazil.
National Institutes of Science and Technology in Tropical Diseases, Ministry of Science and Technology, Salvador, Bahia, Brazil.
Pathogens. 2024 Apr 4;13(4):301. doi: 10.3390/pathogens13040301.
Cutaneous leishmaniasis (CL), caused by in recent decades has shown decreasing cure rates after treatment with meglumine antimoniate (MA). Granulocyte colony-stimulating factor (G-CSF) is a cytokine associated with epithelialization and healing processes.
This study compares the effectiveness of G-CSF associated with MA in the treatment of CL. A total of 32 patients aged between 18 and 50 years with CL confirmed for were included in this study. G-CSF or placebo (0.9% saline) was applied by intralesional infiltration at four equidistant points on the edges of the largest ulcer on days 0 and 15 of treatment associated with intravenous MA.
Males predominated in the G-CSF group (59%), while females predominated in the control group (53%). Injuries to the lower limbs predominated in both study groups. The cure rate in the G-CSF group was 65% and in the control group it was 47%, 90 days after initiation of therapy.
Our data indicate that the association of G-CSF with MA is not superior to MA monotherapy. Although not significant, the potential benefit of this combination deserves further investigation. The use of higher doses or other routes of application of G-CSF in a greater number of patients should contribute to a definitive response.
近几十年来，由[病原体名称未给出]引起的皮肤利什曼病（CL）经葡甲胺锑酸盐（MA）治疗后的治愈率呈下降趋势。粒细胞集落刺激因子（G-CSF）是一种与上皮形成和愈合过程相关的细胞因子。
本研究比较了G-CSF联合MA治疗CL的有效性。本研究共纳入32例年龄在18至50岁之间确诊为CL的患者。在与静脉注射MA联合治疗的第0天和第15天，通过病灶内浸润在最大溃疡边缘的四个等距点应用G-CSF或安慰剂（0.9%生理盐水）。
G-CSF组男性占主导（59%），而对照组女性占主导（53%）。两个研究组中下肢损伤均占主导。治疗开始90天后，G-CSF组的治愈率为65%，对照组为47%。
我们的数据表明，G-CSF与MA联合使用并不优于MA单一疗法。尽管不显著，但这种联合使用的潜在益处值得进一步研究。在更多患者中使用更高剂量或其他G-CSF给药途径应有助于得出明确的结果。
