Bock Troels
Research Laboratory for Stereology and Neuroscience, H:S Bispebjerg Hospital, Copenhagen, Denmark.
Bioessays. 2004 Nov;26(11):1156-9. doi: 10.1002/bies.20143.
The natural source for new pancreatic beta cells is an important issue both for understanding the pathogenesis of diabetes, and for possibly curing diabetes by increasing the number of beta cells. Dor et al. investigated beta-cell renewal and regeneration by genetic lineage analysis in mice during physiological growth and after partial pancreatectomy. The data conclusively showed that beta-cell replication was the only source for new beta cells without contributions from stem cells or other non-beta cells. This underlines the capacity for beta-cell self-renewal and casts doubt that other cell types are able to generate new beta cells in the intact pancreas.
新的胰腺β细胞的天然来源是一个重要问题，这对于理解糖尿病的发病机制以及通过增加β细胞数量来治愈糖尿病都很关键。多尔等人通过基因谱系分析研究了小鼠在生理生长过程中和部分胰腺切除术后β细胞的更新和再生。数据确凿地表明，β细胞复制是新β细胞的唯一来源，干细胞或其他非β细胞没有贡献。这突出了β细胞自我更新的能力，并对其他细胞类型能否在完整胰腺中产生新的β细胞提出了质疑。
