Contour-Galcéra Marie-Odile, Lavergne Olivier, Brezak Marie-Christine, Ducommun Bernard, Prévost Grégoire
Ipsen Research Laboratories, Institut Henri Beaufour, 5, Avenue du Canada, F-91966 Les Ulis Cédex, France.
Bioorg Med Chem Lett. 2004 Dec 6;14(23):5809-12. doi: 10.1016/j.bmcl.2004.09.041.
A targeted library of small molecules has been prepared to optimize the biological activity of BN82002, our initial lead compound, recently described as an original inhibitor of CDC25 phosphatases. Some of these compounds inhibit CDC25 in the micromolar range and therefore reinforce the interest of CDC25 as an anticancer target.
已制备了一个小分子靶向文库，以优化BN82002（我们最初的先导化合物，最近被描述为CDC25磷酸酶的新型抑制剂）的生物活性。其中一些化合物在微摩尔范围内抑制CDC25，因此增强了将CDC25作为抗癌靶点的研究意义。
