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相似文献

1
An exclusion map for pre-eclampsia: assuming autosomal recessive inheritance.子痫前期的排除图谱：假设为常染色体隐性遗传。
Am J Hum Genet. 1992 Apr;50(4):749-57.
2
A follow-up linkage study of Finnish pre-eclampsia families identifies a new fetal susceptibility locus on chromosome 18.一项对芬兰子痫前期家族的随访连锁研究确定了 18 号染色体上新的胎儿易感性位点。
Eur J Hum Genet. 2013 Sep;21(9):1024-6. doi: 10.1038/ejhg.2013.6. Epub 2013 Feb 6.
3
What is the place of genetics in the pathogenesis of pre-eclampsia?遗传学在子痫前期发病机制中处于什么地位？
Biol Neonate. 1999 Dec;76(6):325-30. doi: 10.1159/000014175.
4
A genome-wide scan reveals a maternal susceptibility locus for pre-eclampsia on chromosome 2p13.一项全基因组扫描揭示了2号染色体p13区域上一个子痫前期的母体易感性位点。
Hum Mol Genet. 1999 Sep;8(9):1799-805. doi: 10.1093/hmg/8.9.1799.
5
Absence of close linkage between maternal genes for susceptibility to pre-eclampsia/eclampsia and HLA DR beta.子痫前期/子痫易感性的母体基因与HLA DRβ之间不存在紧密连锁。
Lancet. 1990 Sep 15;336(8716):653-7. doi: 10.1016/0140-6736(90)92149-c.
6
Pre-eclampsia and trisomy 13: a possible association.子痫前期与13三体综合征：一种可能的关联。
Lancet. 1987 Aug 22;2(8556):425-7. doi: 10.1016/s0140-6736(87)90960-3.
7
Identification of two novel quantitative trait loci for pre-eclampsia susceptibility on chromosomes 5q and 13q using a variance components-based linkage approach.使用基于方差成分的连锁分析方法，在5号染色体和13号染色体上鉴定出两个与子痫前期易感性相关的新数量性状基因座。
Mol Hum Reprod. 2007 Jan;13(1):61-7. doi: 10.1093/molehr/gal095. Epub 2006 Nov 4.
8
The indicence of severe pre-eclampsia amongst mothers and mothers-in-law of pre-eclamptics and controls.子痫前期患者及对照者的母亲和婆婆中重度子痫前期的发病率。
Br J Obstet Gynaecol. 1981 Aug;88(8):785-91. doi: 10.1111/j.1471-0528.1981.tb01304.x.
9
Genetic and familial predisposition to eclampsia and pre-eclampsia in a defined population.特定人群中子痫和子痫前期的遗传及家族易感性。
Br J Obstet Gynaecol. 1990 Sep;97(9):762-9. doi: 10.1111/j.1471-0528.1990.tb02569.x.
10
Influence of human leukocyte antigen and tumour necrosis factor genes on the development of pre-eclampsia.人类白细胞抗原和肿瘤坏死因子基因对先兆子痫发展的影响。
Hum Reprod Update. 1999 Mar-Apr;5(2):94-102. doi: 10.1093/humupd/5.2.94.

引用本文的文献

1
[Association between - gene polymorphisms and genetic susceptibility of early-onset severe preeclampsia].[-基因多态性与早发型重度子痫前期遗传易感性的关联]
Zhongguo Dang Dai Er Ke Za Zhi. 2023 Oct 15;25(10):1022-1027. doi: 10.7499/j.issn.1008-8830.2303100.
2
Candidate Gene, Genome-Wide Association and Bioinformatic Studies in Pre-eclampsia: a Review.候选基因、全基因组关联和生物信息学研究在子痫前期中的应用：综述。
Curr Hypertens Rep. 2018 Aug 29;20(10):91. doi: 10.1007/s11906-018-0891-x.
3
Refined phenotyping identifies links between preeclampsia and related diseases in a Norwegian preeclampsia family cohort.精细表型分析揭示挪威子痫前期家系队列中子痫前期与相关疾病之间的联系。
J Hypertens. 2015 Nov;33(11):2294-302. doi: 10.1097/HJH.0000000000000696.
4
Pathophysiology and maternal biologic markers of preeclampsia.子痫前期的病理生理学及母体生物学标志物
Endocrine. 2002 Oct;19(1):113-25. doi: 10.1385/ENDO:19:1:113.
5
Susceptibility loci for preeclampsia on chromosomes 2p25 and 9p13 in Finnish families.芬兰家族中位于2号染色体2p25和9号染色体9p13区域的子痫前期易感性基因座。
Am J Hum Genet. 2003 Jan;72(1):168-77. doi: 10.1086/345311. Epub 2002 Dec 9.
6
Evidence for a familial pregnancy-induced hypertension locus in the eNOS-gene region.内皮型一氧化氮合酶基因区域存在家族性妊娠高血压位点的证据。
Am J Hum Genet. 1997 Aug;61(2):354-62. doi: 10.1086/514843.
7
A genomewide linkage study of preeclampsia/eclampsia reveals evidence for a candidate region on 4q.一项关于先兆子痫/子痫的全基因组连锁研究揭示了4号染色体长臂上一个候选区域的相关证据。
Am J Hum Genet. 1997 May;60(5):1158-67.
8
Concerns about the genetics of pre-eclampsia.关于子痫前期遗传学的担忧。
Am J Hum Genet. 1993 May;52(5):1012-4.
9
Hypertension in pregnancy.妊娠期高血压
Arch Dis Child Fetal Neonatal Ed. 1995 Mar;72(2):F139-44. doi: 10.1136/fn.72.2.f139.
10
The hypertensive disorders of pregnancy.妊娠期高血压疾病
BMJ. 1995 Sep 2;311(7005):609-13. doi: 10.1136/bmj.311.7005.609.

本文引用的文献

1
Some observations on the incidence of pre-eclampsia.关于子痫前期发病率的一些观察
J Obstet Gynaecol Br Emp. 1958 Aug;65(4):536-9. doi: 10.1111/j.1471-0528.1958.tb08557.x.
2
The indicence of severe pre-eclampsia amongst mothers and mothers-in-law of pre-eclamptics and controls.子痫前期患者及对照者的母亲和婆婆中重度子痫前期的发病率。
Br J Obstet Gynaecol. 1981 Aug;88(8):785-91. doi: 10.1111/j.1471-0528.1981.tb01304.x.
3
Factor VIII complex in normal pregnancy, pre-eclampsia and fetal growth retardation.正常妊娠、子痫前期及胎儿生长受限中的凝血因子 VIII 复合物
Br J Obstet Gynaecol. 1981 Mar;88(3):250-4. doi: 10.1111/j.1471-0528.1981.tb00977.x.
4
Strategies for multilocus linkage analysis in humans.人类多位点连锁分析策略。
Proc Natl Acad Sci U S A. 1984 Jun;81(11):3443-6. doi: 10.1073/pnas.81.11.3443.
5
Linkage disequilibrium and evolutionary relationships of DNA variants (restriction enzyme fragment length polymorphisms) at the serum albumin locus.血清白蛋白基因座处DNA变异（限制性酶切片段长度多态性）的连锁不平衡及进化关系。
Proc Natl Acad Sci U S A. 1984 Jun;81(11):3486-90. doi: 10.1073/pnas.81.11.3486.
6
The familial factor in toxemia of pregnancy.妊娠中毒症中的家族因素。
Obstet Gynecol. 1968 Sep;32(3):303-11.
7
Genetics of hypertension in pregnancy: possible single gene control of pre-eclampsia and eclampsia in the descendants of eclamptic women.妊娠期高血压的遗传学：子痫妇女后代中先兆子痫和子痫可能受单基因控制。
Br J Obstet Gynaecol. 1986 Sep;93(9):898-908. doi: 10.1111/j.1471-0528.1986.tb08006.x.
8
Exclusion mapping.排除性定位
J Med Genet. 1987 Sep;24(9):539-43. doi: 10.1136/jmg.24.9.539.
9
Characterization of a panel of highly variable minisatellites cloned from human DNA.从人类DNA中克隆的一组高度可变微卫星的特征分析。
Ann Hum Genet. 1987 Oct;51(4):269-88. doi: 10.1111/j.1469-1809.1987.tb01062.x.
10
Genetic control of susceptibility to eclampsia and miscarriage.子痫和流产易感性的遗传控制。
Br J Obstet Gynaecol. 1988 Jul;95(7):644-53. doi: 10.1111/j.1471-0528.1988.tb06524.x.

子痫前期的排除图谱：假设为常染色体隐性遗传。

An exclusion map for pre-eclampsia: assuming autosomal recessive inheritance.

作者信息

Hayward C, Livingstone J, Holloway S, Liston W A, Brock D J

机构信息

Human Genetics Unit, University of Edinburgh, Western General Hospital, Scotland.

出版信息

Am J Hum Genet. 1992 Apr;50(4):749-57.

PMID:1550119
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1682648/
Abstract

Pre-eclampsia is a common complication of the second half of pregnancy that is associated with substantial fetal and maternal morbidity. Although the genetic basis of the disorder is unclear, epidemiological studies suggest that it occurs predominantly in the first pregnancies of women who are homozygous for a relatively common susceptibility gene. Using this epidemiological model, we have begun to construct an exclusion map by using both candidate genes and random DNA markers on a panel of two-generation families in which pre-eclampsia was rigorously defined. No evidence was found for linkage to the HLA region or to several genes implicated in the pathogenesis of hypertension.

摘要

子痫前期是妊娠后半期常见的并发症，与胎儿和母亲的高发病率相关。尽管该疾病的遗传基础尚不清楚，但流行病学研究表明，它主要发生在携带相对常见易感基因纯合子的女性的首次妊娠中。利用这一流行病学模型，我们开始在严格定义了子痫前期的两代家系样本上，通过使用候选基因和随机DNA标记构建排除图谱。未发现与HLA区域或与高血压发病机制相关的几个基因存在连锁关系。