子痫前期的排除图谱：假设为常染色体隐性遗传。
An exclusion map for pre-eclampsia: assuming autosomal recessive inheritance.
作者信息
Hayward C, Livingstone J, Holloway S, Liston W A, Brock D J
机构信息
Human Genetics Unit, University of Edinburgh, Western General Hospital, Scotland.
出版信息
Am J Hum Genet. 1992 Apr;50(4):749-57.
Abstract
Pre-eclampsia is a common complication of the second half of pregnancy that is associated with substantial fetal and maternal morbidity. Although the genetic basis of the disorder is unclear, epidemiological studies suggest that it occurs predominantly in the first pregnancies of women who are homozygous for a relatively common susceptibility gene. Using this epidemiological model, we have begun to construct an exclusion map by using both candidate genes and random DNA markers on a panel of two-generation families in which pre-eclampsia was rigorously defined. No evidence was found for linkage to the HLA region or to several genes implicated in the pathogenesis of hypertension.
摘要
子痫前期是妊娠后半期常见的并发症，与胎儿和母亲的高发病率相关。尽管该疾病的遗传基础尚不清楚，但流行病学研究表明，它主要发生在携带相对常见易感基因纯合子的女性的首次妊娠中。利用这一流行病学模型，我们开始在严格定义了子痫前期的两代家系样本上，通过使用候选基因和随机DNA标记构建排除图谱。未发现与HLA区域或与高血压发病机制相关的几个基因存在连锁关系。
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