Pastila S, Sammalkorpi K T, Vuopio-Varkila J, Kontiainen S, Ristola M A
Kanta-Häme Central Hospital, 13530 Hämeenlinna, Finland.
J Hosp Infect. 2004 Nov;58(3):180-6. doi: 10.1016/j.jhin.2004.06.024.
This population-based, retrospective, cohort study describes a large methicillin-resistant Staphylococcus aureus (MRSA) epidemic caused by one strain (E1) in the greater Helsinki region. The epidemic comprised 210 cases at several hospitals, but was finally controlled. The study period ranged from June 1991 to December 2000. The epidemic peaked in 1993-1995 with 143 cases (68% of total cases). From August 1993, all MRSA-positive cases at the eight municipal hospitals were isolated and barrier nursed. Contacts were cohorted and screened for MRSA colonization. Decolonization treatment was administered to some chronic carriers. MRSA cases and contacts were identified in the joint patient register of the municipal hospitals from August 1993. The annual incidence of MRSA E1 in Helsinki City area per 100,000 inhabitants rose from 0.2 in 1991 to 13.6 in 1994. It decreased from 1995, reaching 0.7 per 100,000 in 2000. A jointly agreed policy on MRSA and timely co-operation between all units were essential for control of this epidemic.
这项基于人群的回顾性队列研究描述了大赫尔辛基地区由一种菌株（E1）引起的大规模耐甲氧西林金黄色葡萄球菌（MRSA）疫情。该疫情在几家医院共涉及210例病例，但最终得到了控制。研究期间为1991年6月至2000年12月。疫情在1993 - 1995年达到高峰，有143例病例（占总病例数的68%）。从1993年8月起，八家市立医院所有MRSA阳性病例均被隔离并进行屏障护理。对接触者进行群组划分并筛查MRSA定植情况。对一些慢性携带者进行了去定植治疗。从1993年8月起，在市立医院的联合患者登记册中识别出MRSA病例和接触者。赫尔辛基市地区每10万居民中MRSA E1的年发病率从1991年的0.2上升至1994年的13.6。从1995年开始下降，到2000年降至每10万居民0.7。关于MRSA的共同商定政策以及所有单位之间的及时合作对于控制此次疫情至关重要。
