Arida Ricardo Mario, Sanabria Emilio Rafael Garrido, da Silva Andre Cesar, Faria Leonardo Coutinho, Scorza Fulvio Alexandre, Cavalheiro Esper Abrão
Laboratório de Neurologia Experimental, Universidade Federal de São Paulo-Escola Paulista de Medicina (UNIFESP/EPM), Rua Botucatú 862, Vila Clementino, CEP 04023-900 São Paulo, Brazil.
Physiol Behav. 2004 Oct 30;83(1):165-71. doi: 10.1016/j.physbeh.2004.08.008.
Physical exercise and fitness programs in patients with epilepsy are still a matter of controversy. Effects of physical exercise in animals with epilepsy have been demonstrated. To further investigate the possible mechanisms by which physical activity interferes with epileptogenesis, the present work was aimed to study the effect of aerobic exercise on "in vitro" hippocampal electrophysiological parameters observed in rats submitted to the pilocarpine model of epilepsy. Electrophysiological changes were monitored by extracellular field potentials recorded from CA1 area. Control rats and rats with epilepsy were submitted to an aerobic exercise program. The number of population spikes (PS) and slope of field excitatory postsynaptic potentials (fEPSP) were analyzed. Trained rats with epilepsy exhibited a reduction in PS when compared with nontrained rats with epilepsy in different concentrations of extracellular potassium or bicuculline. Physical training also enhanced the late phase of LTP in rats with epilepsy. Our results indicate that physical training reduces CA1 hyperresponsiveness and can modify synaptic plasticity in rats submitted to the pilocarpine model of limbic epilepsy.
癫痫患者的体育锻炼和健身计划仍然存在争议。体育锻炼对癫痫动物的影响已经得到证实。为了进一步研究体育活动干扰癫痫发生的可能机制，本研究旨在探讨有氧运动对癫痫匹罗卡品模型大鼠“体外”海马电生理参数的影响。通过记录CA1区的细胞外场电位来监测电生理变化。将对照大鼠和癫痫大鼠纳入有氧运动计划。分析群体峰电位（PS）的数量和场兴奋性突触后电位（fEPSP）的斜率。与未训练的癫痫大鼠相比，经过训练的癫痫大鼠在不同浓度的细胞外钾或荷包牡丹碱作用下PS减少。体育训练还增强了癫痫大鼠的长时程增强（LTP）后期。我们的结果表明，体育训练可降低CA1区的高反应性，并可改变癫痫匹罗卡品模型大鼠的突触可塑性。
